Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis
Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis
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DOI：
10.1038/sj.bjp.0702283
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发表时间：
1999-01-01
影响因子：
7.3
通讯作者：
Lazdunski, M
中科院分区：
文献类型：
--
作者：
Diochot, S;Drici, MD;Lazdunski, M
在本研究中，从狼蛛（Phrixotrichus auratus）的毒液中纯化出两种新的肽，即phrixotoxin PaTx1和PaTx2（29-31个氨基酸），它们能有效阻断a型钾电流。phrixotoxins特异性阻断I-tol基础上的Kv4.3和Kv4.2电流
1 In the present study, two new peptides, phrixotoxins PaTx1 and PaTx2 (29-31 amino acids), which potently block A-type potassium currents, have been purified from the venom of the tarantula Phrixotrichus auratus.2 phrixotoxins specifically block Kv4.3 and Kv4.2 currents that underlie I-tol, with an 5