FTH1P3, a Novel H-Ferritin Pseudogene Transcriptionally Active, Is Ubiquitously Expressed and Regulated during Cell Differentiation.
FTH1P3, a Novel H-Ferritin Pseudogene Transcriptionally Active, Is Ubiquitously Expressed and Regulated during Cell Differentiation.
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DOI：
10.1371/journal.pone.0151359
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Costanzo F
中科院分区：
文献类型：
--
作者：
Di Sanzo M;Aversa I;Santamaria G;Gagliardi M;Panebianco M;Biamonte F;Zolea F;Faniello MC;Cuda G;Costanzo F
铁蛋白是主要的铁储存蛋白，在细胞质、细胞核和线粒体中发挥其基本功能。重（H）和轻（L）型的24个亚基的可变组装体构成细胞质分子。在人类中，两个不同的基因编码这些亚基，都属于复杂的多基因家族。到目前为止，已经确定了一个H基因，其编码序列被三个内含子中断，并且广泛分布在不同染色体上的20多个无内含子拷贝。其中两个无内含子基因以组织特异性方式活跃转录。在此，我们报告，FTH1P3，另一个无内含子的假基因，转录。在几种细胞系和组织中检测到FTH1P3转录物，表明其转录是普遍存在的，就像亲本铁蛋白H基因一样。此外，FTH1P3表达在细胞分化过程中受到正调控。
Ferritin, the major iron storage protein, performs its essential functions in the cytoplasm, nucleus and mitochondria. The variable assembly of 24 subunits of the Heavy (H) and Light (L) type composes the cytoplasmic molecule. In humans, two distinct genes code these subunits, both belonging to complex multigene families. Until now, one H gene has been identified with the coding sequence interrupted by three introns and more than 20 intronless copies widely dispersed on different chromosomes. Two of the intronless genes are actively transcribed in a tissue-specific manner. Herein, we report that FTH1P3, another intronless pseudogene, is transcribed. FTH1P3 transcript was detected in several cell lines and tissues, suggesting that its transcription is ubiquitary, as it happens for the parental ferritin H gene. Moreover, FTH1P3 expression is positively regulated during the cell differentiation process.