Phosphoinositide signaling in somatosensory neurons.
Phosphoinositide signaling in somatosensory neurons.
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DOI：
10.1016/j.jbior.2015.11.012
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发表时间：
2016-05
影响因子：
--
通讯作者：
Rohacs T
中科院分区：
文献类型：
--
作者：
Rohacs T
背根神经节（DRG）和三叉神经节（TG）的体感神经元负责检测热刺激和触觉刺激。它们也是介导疼痛和瘙痒的主要神经元。这些神经元中的大量细胞表面受体与磷脂酶C（PLC）酶偶联，导致磷脂酰肌醇4，5-二磷酸[PI（4，5）P2]水解并产生下游信号分子。这些神经元还表达许多不同的离子通道，其中几个由磷酸肌醇调节。本文将总结这些神经元中磷酸肌醇信号的知识，特别关注对感觉和其他离子通道的影响。
Somatosensory neurons of the dorsal root ganglia (DRG) and trigeminal ganglia (TG) are responsible for detecting thermal and tactile stimuli. They are also the primary neurons mediating pain and itch. A large number of cell surface receptors in these neurons couple to phospholipase C (PLC) enzymes leading to the hydrolysis of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] and the generation of downstream signaling molecules. These neurons also express many different ion channels, several of which are regulated by phosphoinositides. This review will summarize the knowledge on phosphoinositide signaling in these neurons, with special focus on effects on sensory and other ion channels.