A Capacitive MEMS Viscometric Sensor for Affinity Detection of Glucose.
A Capacitive MEMS Viscometric Sensor for Affinity Detection of Glucose.
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DOI：
10.1109/jmems.2009.2034869
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发表时间：
2009-11-13
期刊：
影响因子：
--
通讯作者：
Lin Q
中科院分区：
文献类型：
--
作者：
Huang X;Li S;Schultz J;Wang Q;Lin Q
提出了一种用于连续血糖监测(CGM)的电容式微电子机械系统亲和传感器。该传感器由一个由磁场远程驱动的振动对苯膜片组成，位于一个微腔内。生物相容性葡萄糖敏感聚合物聚(丙烯酰胺-RAN-3-丙烯酰胺基苯基硼酸)(PAA-RAN-PAAPBA)的溶液填充微室，微室与周围环境用半透膜隔开。葡萄糖透过膜，可逆地与聚合物的苯基硼酸部分结合。这会导致传感溶液的粘度变化，从而导致可以电容式测量的对二甲苯隔膜振动的可检测变化。实验结果表明，该仪器能够在30~360 mg/dL的生理浓度范围内检测葡萄糖。传感器对葡萄糖浓度变化的响应时间约为1.5分钟，通过优化器件设计可以进一步提高响应时间。传感器响应具有极好的可逆性和稳定性，这是长期CGM非常需要的。
This paper presents a capacitively based microelectromechanical systems affinity sensor for continuous glucose monitoring (CGM) applications. This sensor consists of a vibrating Parylene diaphragm, which is remotely driven by a magnetic field and situated inside a microchamber. A solution of poly(acrylamide-ran-3-acrylamidophenylboronic acid) (PAA-ran-PAAPBA), a biocompatible glucose-sensitive polymer, fills the microchamber, which is separated from its surroundings by a semipermeable membrane. Glucose permeates through the membrane and binds reversibly to the phenylboronic acid moiety of the polymer. This results in a viscosity change of the sensing solution, causing a detectable change in the Parylene diaphragm vibration which can be measured capacitively. Experimental results demonstrate that the device is capable of detecting glucose at physiologically relevant concentrations ranging from 30 to 360 mg/dL. The response time of the sensor to glucose concentration changes is approximately 1.5 min, which can be further improved with optimized device designs. Excellent reversibility and stability are observed in sensor responses, as highly desired for long-term CGM.