Piceatannol Prevents Obesity and Fat Accumulation Caused by Estrogen Deficiency in Female Mice by Promoting Lipolysis.
Piceatannol Prevents Obesity and Fat Accumulation Caused by Estrogen Deficiency in Female Mice by Promoting Lipolysis.
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DOI：
10.3390/nu15061374
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发表时间：
2023-03-12
期刊：
影响因子：
5.9
通讯作者：
Fujiwara Y
中科院分区：
文献类型：
--
作者：
Arisawa K;Kaneko M;Matsuoka A;Ozawa N;Kawawa R;Ishikawa T;Ichi I;Fujiwara Y
绝经后女性更容易患肥胖症和慢性病。据报道，白皮杉醇 (PIC) 是白藜芦醇的天然类似物，可抑制脂肪生成并具有抗肥胖作用。本研究探讨了 PIC 对绝经后肥胖的影响及其作用机制。 C57BL/6J雌性小鼠被分为四组，其中一半被切除卵巢（OVX）。 OVX 小鼠和假手术小鼠均采用添加或不添加 0.25% PIC 的高脂饮食 (HFD) 喂养 12 周。 OVX小鼠腹部内脏脂肪体积高于假手术小鼠，PIC仅显着降低OVX小鼠的脂肪体积。出乎意料的是，OVX 小鼠中白色脂肪组织 (WAT) 中脂肪生成相关蛋白的表达水平受到抑制，并且 PIC 不影响 OVX 或假手术小鼠的脂肪生成。关于与脂肪分解相关的蛋白质的表达，PIC在OVX小鼠中更多地激活激素敏感性脂肪酶的磷酸化，但不影响脂肪甘油三酯脂肪酶的表达。 PIC 还倾向于诱导棕色脂肪组织 (BAT) 中未偶联蛋白 1 的表达。这些结果表明，通过促进 WAT 中的脂肪分解和 BAT 中的解结合，PIC 是抑制更年期引起的脂肪积累的潜在药物。
Postmenopausal women have a higher susceptibility to obesity and chronic disease. Piceatannol (PIC), a natural analog of resveratrol, was reported to inhibit adipogenesis and to have an antiobesity effect. In this study, PIC’s effect on postmenopausal obesity and the mechanism of its action were investigated. C57BL/6J female mice were divided into four groups and half of them were ovariectomized (OVX). Both OVX and sham-operated mice were fed a high-fat diet (HFD) with and without the addition of 0.25% of PIC for 12 weeks. The abdominal visceral fat volume was higher in the OVX mice than the sham-operated mice, and PIC significantly decreased the fat volume only in the OVX mice. Unexpectedly, expression levels of adipogenesis-related proteins in white adipose tissue (WAT) were suppressed in the OVX mice, and PIC did not affect lipogenesis in either the OVX or sham-operated mice. Regarding the expression of proteins associated with lipolysis, PIC activated the phosphorylation of hormone-sensitive lipase much more in the OVX mice, but it did not affect the expression of adipose triglyceride lipase. PIC also tended to induce the expression of uncoupled protein 1 in brown adipose tissue (BAT). These results suggest that by promoting lipolysis in WAT and deconjugation in BAT, PIC is a potential agent to inhibit fat accumulation caused by menopause.