CRYPTOSPORIDIOSIS IN INFANCY AND CHILDHOOD MORTALITY IN GUINEA-BISSAU, WEST-AFRICA
CRYPTOSPORIDIOSIS IN INFANCY AND CHILDHOOD MORTALITY IN GUINEA-BISSAU, WEST-AFRICA
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DOI：
10.1136/bmj.307.6901.417
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发表时间：
1993-08-14
影响因子：
--
通讯作者：
AABY, P
中科院分区：
文献类型：
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作者：
MOLBAK, K;HOJLYNG, N;AABY, P
研究西非几内亚比绍幼儿隐孢子虫病的流行病学和死亡率。设计-每周随访的开放队列的三年社区研究。设置-在首都半城市地区随机选择301所房屋，比绍。受试者-1315名4岁以下儿童。主要结果测量-隐孢子虫感染检测腹泻和死亡的child. Results-Cryptosporidiumspp的发作期间的粪便检查被发现在239（7.4%）的3215腹泻发作。这种寄生虫在幼儿（中位年龄12个月）和雨季开始时最常见。持续性腹泻病例中隐孢子虫病的患病率为15%（77/513），而持续不到两周的腹泻病例中隐孢子虫病的患病率为6.1%（148/2428）（p < 0-0001）。隐孢子虫病与婴儿期感染的儿童死亡率过高有关，这种过高的死亡率持续到生命的第二年（相对死亡率2.9（95%置信区间1.7至4.9））。过多的死亡率不能解释营养不良，或社会经济因素，卫生条件，或母乳喂养。结论隐孢子虫病是一个重要的原因，否则健康的儿童在发展中国家的死亡。
Objective-To investigate the epidemiology of and mortality from cryptosporidiosis in young children in Guinea Bissau, West Africa.Design-Three year community study of an open cohort followed up weekly.Setting-301 randomly selected houses in a semi-urban area in the capital, Bissau.Subjects-1315 children aged less than 4 years.Main outcome measures-Cryptosporidium infection detected by examination of stools during episode of diarrhoea and death of a child.Results-Cryptosporidium spp were found in 239 (7.4%) out of 3215 episodes of diarrhoea. The parasite was most common in younger children (median age 12 months) and at the beginning of the rainy seasons. The prevalence of cryptosporidiosis was 15% (77/513) in cases of persistent diarrhoea compared with 6.1% (148/2428) in diarrhoea lasting less than two weeks (p < 0-0001). Cryptosporidiosis was associated with excess mortality in children who had the infection in infancy, and this excess mortality persisted into the second year of life (relative mortality 2.9 (95% confidence interval 1.7 to 4.9)). The excess mortality could not be explained by malnutrition, or by socioeconomic factors, hygienic conditions, or breast feeding.Conclusions-Cryptosporidiosis is an important cause of death in otherwise healthy children in developing countries.