Analysis of Globule Types in Malignant Melanoma
Analysis of Globule Types in Malignant Melanoma
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DOI：
10.1001/archdermatol.2009.285
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发表时间：
2009-11-01
影响因子：
--
通讯作者：
Celebi, M. Emre
中科院分区：
文献类型：
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作者：
Xu, Jin;Gupta, Kapil;Celebi, M. Emre
目的：根据大小、形状、网络连通性、色素沉着和分布来识别和分析小球的亚型，以确定哪种小球类型和小球分布与恶性黑色素瘤的诊断最相关。设计：回顾性病例系列的皮肤镜图像与小球。设置：私人皮肤科诊所。参与者：皮肤科诊所的患者。干预：仅观察。主要结果测量：结果：在所有研究的小球类型和组合中，大小球（比值比[OR]，5.25）和大小（4.72）或形状（5.37）不同的小球的存在对恶性黑色素瘤具有最高的OR。典型的小球（深色、离散、凸起和0.10-0.20 mm）比不规则形状的小球（深色、离散和一般不凸起）（2.89）具有更高的风险（OR，4.20）。与其他结构相连的小球对恶性黑色素瘤的诊断意义不大。在研究的不同配置中，不对称簇具有最高的风险（OR，3.02）。结论：在本研究中，不同大小或形状的小球的存在似乎比任何其他小球类型或分布更与恶性黑色素瘤的诊断相关。大的小球在恶性黑色素瘤的诊断中特别重要。
Objective: To identify and analyze subtypes of globules based on size, shape, network connectedness, pigmentation, and distribution to determine which globule types and globule distributions are most frequently associated with a diagnosis of malignant melanoma.Design: Retrospective case series of dermoscopy images with globules.Setting: Private dermatology practices.Participants: Patients in dermatology practices.Intervention: Observation only.Main Outcome Measure: Association of globule types with malignant melanoma.Results: The presence of large globules (odds ratio [OR], 5.25) and globules varying in size (4.72) or shape (5.37) had the highest ORs for malignant melanoma among all globule types and combinations studied. Classical globules (dark, discrete, convex, and 0.10-0.20 mm) had a higher risk (OR, 4.20) than irregularly shaped globules (dark, discrete, and not generally convex) (2.89). Globules connected to other structures were not significant in the diagnosis of malignant melanoma. Of the different configurations studied, asymmetric clusters have the highest risk (OR, 3.02).Conclusions: The presence of globules of varying size or shape seems to be more associated with a diagnosis of malignant melanoma than any other globule type or distribution in this study. Large globules are of particular importance in the diagnosis of malignant melanoma.