Impact of the elevated angiopoietin-2 levels during Impella support on the short-term prognosis
Impact of the elevated angiopoietin-2 levels during Impella support on the short-term prognosis
复制标题
Impella 支持期间血管生成素 2 水平升高对短期预后的影响
DOI：
10.1007/s10047-022-01347-y
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发表时间：
2022
影响因子：
1.3
通讯作者：
Kinugawa Koichiro
中科院分区：
文献类型：
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作者：
Nakamura Makiko;Imamura Teruhiko;Ueno Hiroshi;Kinugawa Koichiro
患有急性心肌梗塞相关的心源性休克（无论是否使用主动脉内球囊反搏）以及急性失代偿性心力衰竭患者的血清血管生成素-2 水平升高与短期死亡率相关。然而，其对由 Impella 机械循环支持 (MCS) 支持的心源性休克患者的预后影响仍不清楚。本前瞻性研究纳入了2018年8月至2022年1月期间在我院接受临时MCS（单独Impella或Impella联合静脉-动脉体外膜氧合）的患者。在开始临时 MCS 治疗之前和之后测量血管生成素-2 的血清水平。研究了血清血管生成素 2 水平与 30 天死亡率之间的关联。总共包括 38 名患者（中位年龄 72 岁，63% 为男性）。血清血管生成素-2 的中位水平从基线下降到开始临时 MCS 后 4 天，从 5.2 (3.3, 10.5) ng/mL 降至 4.8 (2.7, 6.8) ng/mL (p= 0.132)。开始临时 MCS 后较高的血管生成素 2 (> 6.8 ng/mL) 与较高的 30 天死亡率相关（89.7% 对比 44.4%，p= 0.0048），调整潜在混杂因素后，优势比为 18.946（95% 置信区间 1.624–218.695，p= 0.018）。开始 Impella 合并临时 MCS 后较高的血清血管生成素 2 水平（而不是基线血管生成素 2 水平）与较高的短期死亡率相关。
Elevated serum angiopoietin-2 levels in patients with acute myocardial infarction-related cardiogenic shock with and without intra-aortic balloon pump as well as acute decompensated heart failure are associated with short-term mortality. However, its prognostic impact in patients with cardiogenic shock supported by Impella-incorporated mechanical circulatory support (MCS) remains unknown. Patients who received temporary MCS (Impella alone or Impella and veno-arterial extracorporeal membrane oxygenation) in our institute between August 2018 and January 2022 were included in this prospective study. The serum levels of angiopoietin-2 were measured just before and following the initiation of temporary MCS therapy. Association between the levels of serum angiopoietin-2 and 30-day mortality was investigated. A total of 38 patients (median 72 years old, 63% men) were included. The median levels of serum angiopoetin-2 tended to decrease from baseline to 4 days following the initiation of temporary MCS from 5.2 (3.3, 10.5) ng/mL to 4.8 (2.7, 6.8) ng/mL (p= 0.132). A higher angiopoietin-2 (> 6.8 ng/mL) following the initiation of temporary MCS was associated with higher 30-day mortality (89.7% versus 44.4%,p= 0.0048) with an odds ratio 18.946 (95% confidence interval 1.624–218.695,p= 0.018) adjusted for potential confounders. A higher serum angiopoietin-2 level following the initiation of Impella-incorporated temporary MCS, instead of baseline angiopoetin-2 level, was associated with higher short-term mortality.
影响因子：
120.7
作者：
Samsky, Marc D.;Morrow, David A.;Proudfoot, Alastair G.;Hochman, Judith S.;Thiele, Holger;Rao, Sunil V.
通讯作者：
Rao, Sunil V.
教师意见建议急性心肌梗死并发心源性休克的早期机械循环支持的可行性：底特律心源性休克倡议。
DOI：
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发表时间：
2020
期刊：
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
影响因子：
--
作者：
N. Kapur
通讯作者：
N. Kapur
影响因子：
37.8
作者：
Hochman, JS
通讯作者：
Hochman, JS