Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
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DOI：
10.1038/ni.1767
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发表时间：
2009-08-01
影响因子：
30.5
通讯作者：
Sallusto, Federica
中科院分区：
文献类型：
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作者：
Duhen, Thomas;Geiger, Rebekka;Sallusto, Federica
白细胞介素22（IL-22）是由辅助性T细胞的T-H-17谱系和自然杀伤细胞的NK-22亚群产生的细胞因子，其作用于上皮细胞和角质形成细胞，并且与皮肤稳态和炎症有关。在这里，我们描述了一群人类皮肤归巢记忆CD 4（+）T细胞，表达趋化因子受体CCR 10，CCR 6和CCR 4，产生IL-22，但既不产生IL-17，也不产生干扰素-γ（IFN-γ）。从该群体中分离的克隆仅产生IL-22，并且具有低表达或检测不到的T-H-17和T辅助1型（T（H）1）转录因子ROR γ t和T-bet表达。浆细胞样树突状细胞以IL-6和肿瘤坏死因子依赖的方式有效诱导幼稚T细胞中仅产生IL-22的T细胞的分化。我们的研究结果描绘了一个以前未知的致力于皮肤病理生理学的人类CD 4（+）效应T细胞亚群。
Interleukin 22 (IL-22) is a cytokine produced by the T-H-17 lineage of helper T cells and NK-22 subset of natural killer cells that acts on epithelial cells and keratinocytes and has been linked to skin homeostasis and inflammation. Here we characterize a population of human skin-homing memory CD4(+) T cells that expressed the chemokine receptors CCR10, CCR6 and CCR4 and produced IL-22 but neither IL-17 nor interferon-gamma (IFN-gamma). Clones isolated from this population produced IL-22 only and had low or undetectable expression of the T-H-17 and T helper type 1 (T(H)1) transcription factors ROR gamma t and T-bet. The differentiation of T cells producing only IL-22 was efficiently induced in naive T cells by plasmacytoid dendritic cells in an IL-6- and tumor necrosis factor-dependent way. Our findings delineate a previously unknown subset of human CD4(+) effector T cells dedicated to skin pathophysiology.