A neural substrate of sex-dependent modulation of motivation.
A neural substrate of sex-dependent modulation of motivation.
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性别依赖性动机调节的神经基础。
DOI：
10.1038/s41593-022-01229-9
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发表时间：
2023
影响因子：
25
通讯作者：
Witten,IlanaB
中科院分区：
文献类型：
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作者：
Cox,Julia;Minerva,AdelaideR;Fleming,WestonT;Zimmerman,ChristopherA;Hayes,Cameron;Zorowitz,Samuel;Bandi,Akhil;Ornelas,Sharon;McMannon,Brenna;Parker,NathanF;Witten,IlanaB
尽管越来越多的证据表明决策行为存在性别差异，但造成这种差异的神经基础仍然很大程度上未知。在这里，我们证明，在执行基于价值的决策任务的小鼠中，虽然性别之间的选择相似，但女性参与任务的动机比男性更强烈地受到行动价值的调节。抑制投射到背内侧纹状体（DMS）的前扣带皮层（ACC）神经元的活动会优先破坏女性价值和动机之间的关系，而不影响任何性别的选择。与这些效应一致，与男性相比，女性中的 ACC-DMS 神经元对负面结果具有更强的表征，并且当所选选项的价值较低时，更多的神经元处于活动状态。相比之下，每个选择的代表性在性别之间是相似的。因此，我们确定了一种神经基质，有助于通过价值对动机进行性别特异性调节。
While there is emerging evidence of sex differences in decision-making behavior, the neural substrates that underlie such differences remain largely unknown. Here we demonstrate that in mice performing a value-based decision-making task, while choices are similar between the sexes, motivation to engage in the task is modulated by action value more strongly in females than in males. Inhibition of activity in anterior cingulate cortex (ACC) neurons that project to the dorsomedial striatum (DMS) preferentially disrupts this relationship between value and motivation in females, without affecting choice in either sex. In line with these effects, in females compared to males, ACC–DMS neurons have stronger representations of negative outcomes and more neurons are active when the value of the chosen option is low. By contrast, the representation of each choice is similar between the sexes. Thus, we identify a neural substrate that contributes to sex-specific modulation of motivation by value.