Acute phase HBV-specific T cell responses associated with HBV persistence after HBV/HCV coinfection
Acute phase HBV-specific T cell responses associated with HBV persistence after HBV/HCV coinfection
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DOI：
10.1002/hep.20614
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发表时间：
2005-04-01
期刊：
影响因子：
13.5
通讯作者：
Ferrari, C
中科院分区：
文献类型：
--
作者：
Urbani, S;Boni, C;Ferrari, C
为了表征与自限性和持续性HBV感染相关的急性期B型肝炎病毒（HBV）特异性T细胞应答，我们比较了一名能够控制HCV但发展为慢性B型肝炎的急性HBV/HCV合并感染患者与自发缓解急性HBV感染的患者。急性期CD 4应答在自限性感染中有效，但在HBV持续性合并感染患者中检测不到。CD 8应答是多特异性的，与感染的结果无关，但与HBV持续相关的CD 8库缺乏自限性感染中可检测到的最主要特异性。总之，CD 4辅助不足和CD 8库缺陷可能在感染早期影响HBV持续存在。
To characterize acute-phase hepatitis B virus (HBV)-specific T cell responses associated with self-limited and persistent HBV infections, we compared a patient with acute HBV/HCV coinfection, who was able to control HCV but developed chronic hepatitis B, with patients who resolved acute HBV infection spontaneously. Acute-phase CD4 responses were efficient in self-limited infections but undetectable in the coinfected patient with HBV persistence. CD8 responses were multispecific irrespective of the outcome of infection, but the CD8 repertoire associated with HBV persistence lacked the most dominant specificities detectable in self-limited infections. In conclusion insufficient CD4 help and defective CD8 repertoire may play a role at the early stages of infection in influencing HBV persistence.