Effects of zinc supplementation on the plasma glucose level and insulin activity in genetically obese (ob/ob) mice
Effects of zinc supplementation on the plasma glucose level and insulin activity in genetically obese (ob/ob) mice
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DOI：
10.1007/bf02789090
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发表时间：
1998-03-01
影响因子：
3.9
通讯作者：
Lin, WH
中科院分区：
文献类型：
--
作者：
Chen, MD;Liou, SJ;Lin, WH
在遗传性肥胖（ob/ob）小鼠及其瘦小鼠中研究了补充锌（从饮用水中补充20 mM ZnCl 2，持续八周）对血糖和胰岛素水平的影响，以及其对脂肪细胞脂肪生成和脂肪分解的体外影响。对照组（+/？）。补充锌可使肥胖小鼠和瘦小鼠的空腹血糖水平分别降低21%和25%（p < 0.05）。在锌治疗后，肥胖小鼠的空腹血浆胰岛素水平显著降低了42%。在肥胖小鼠中，补充锌也使葡萄糖负荷后的血糖反应减弱了34%。在瘦小鼠中，锌对脂肪细胞中脂肪生成的胰岛素样作用显著增加了80%。然而，只有当给予锌加胰岛素治疗时，才观察到肥胖小鼠脂肪生成增加74%。本研究提示，补锌可减轻ob/ob小鼠的高血糖，这可能与其增强胰岛素活性的作用有关。
The effects of zinc supplementation (20 mM ZnCl2 from the drinking water for eight weeks) on plasma glucose and insulin levels, as well as its in vitro effect on lipogenesis and lipolysis in adipocytes were studied in genetically obese (ob/ob) mice and their lean controls (+/?). Zinc supplementation reduced the fasting plasma glucose levels in both obese and lean mice by 21 and 25%, respectively (p < 0.05). Fasting plasma insulin levels were significantly decreased by 42% in obese mice after zinc treatment. In obese mice, zinc supplementation also attenuated the glycemic response by 34% after the glucose load. The insulin-like effect of zinc on lipogenesis in adipocytes was significantly increased by 80% in lean mice. However, the increment of 74% on lipogenesis in obese mice was observed only when the zinc plus insulin treatment was given. This study reveals that zinc supplementation alleviated the hyperglycemia of ob/ob mice, which may be related to its effect on the enhancement of insulin activity.