Rationale and approaches to constructing preerythrocytic malaria vaccines.
Rationale and approaches to constructing preerythrocytic malaria vaccines.
复制标题
构建红细胞前疟疾疫苗的基本原理和方法。
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
J. Sacci
中科院分区：
文献类型：
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作者：
S. Hoffman;J. Sacci
属于疟原虫属的寄生虫是疟疾的病原体。这种疾病主要在热带地区发现，保守估计每年造成2-3亿新病例，造成约200万人死亡。这种寄生虫有一个复杂的生命周期，当按蚊子孢子阶段的蚊子进食血液时，这种生命周期在宿主中启动。子孢子通过循环传播到肝脏，在那里它们入侵肝细胞。一旦进入肝细胞，寄生虫就会经历一个分化和分裂的周期，这个周期的长度随着物种的不同而不同，最终产生数千个裂殖子，这些裂殖子在肝细胞破裂时重新进入循环。这些处于肝脏阶段的裂殖子侵入红细胞并再次繁殖。48-72小时后，红细胞破裂，释放6-30个裂殖子，然后这些裂殖子可以侵入其他红细胞。一些寄生虫分化为雄配子体和雌配子体，当蚊子摄入配子体时，配子体可以结合形成受精卵，在进一步发育时产生子孢子，可以接种到另一个宿主，从而重复这个循环。
Parasites belonging to the genus Plasmodium are the causative agent for malaria. This disease is primarily found in the tropics and is conservatively estimated to cause 200–300 million new cases each year with approximately 2 million deaths resulting. The parasite has a complex life cycle which is initiated in the host when an anopheline mosquito injects the sporozoite stage as it takes a blood meal. The sporozoites travel through the circulation to the liver where they invade hepatocytes. Once in the hepatocyte the parasite undergoes a cycle of differentiation and division the length of which varies with the species, ultimately producing many thousands of merozoites which reenter the circulation on rupture of the hepatocyte. These liver-stage merozoites invade red blood cells and again multiply. After 48–72 h the red blood cell ruptures, releasing 6–30 merozoites which can then invade other red blood cells. Some parasites differentiate into male and female gametocytes, which when ingested by a mosquito can combine to form a zygote and on further development produce sporozoites that can be inoculated into another host, thereby repeating the cycle.
影响因子：
5.5
作者：
HERRINGTON, DA;LOSONSKY, GA;EDELMAN, R
通讯作者：
EDELMAN, R