Quantitative sensory testing in dogs with painful disease: A window to pain mechanisms?
Quantitative sensory testing in dogs with painful disease: A window to pain mechanisms?
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DOI：
10.1016/j.tvjl.2018.11.007
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发表时间：
2019-01-01
影响因子：
2.2
通讯作者：
Murrell, Jo
中科院分区：
文献类型：
--
作者：
Hunt, James;Knazovicky, David;Murrell, Jo
对外部施加的物理刺激，如压力，热或冷的反应的评估被称为定量感觉测试（QST）。QST可用于识别和量化感觉系统功能的改变（增益或损失），该感觉系统检测和介导人类和动物的这些现象，并可能区分外周和中枢敏化。据推测，QST参数的评价可以预测对镇痛剂的反应，最终增加疼痛治疗的个体化。然而，虽然QST测量和对镇痛剂的反应之间似乎存在相关性，但目前没有足够的证据推荐QST指导临床治疗。在非语言科目中使用心理物理测试（如QST）带来了额外的挑战，需要熟悉物种和个体反应。本叙述性综述描述了迄今为止在临床犬群中对QST的研究，并讨论了此类试验的潜在获益和局限性。(C)2018爱思唯尔有限公司版权所有
Evaluation of the response to externally applied physical stimuli, such as pressure, heat, or cold is termed quantitative sensory testing (QST). QST may be used to identify and quantify alterations (gain or loss) in function of the sensory systems which detect and mediate these phenomena in both man and animals, and potentially discriminate peripheral and central sensitisation. It has been postulated that evaluation of QST parameters may predict response to analgesics, ultimately increasing the individualisation of treatment for pain. However, while there do appear to be correlations between QST measures and responses to analgesics in man, there is currently insufficient evidence to recommend QST to direct clinical treatments. The use of psychophysical testing, such as QST, in non-verbal subjects presents additional challenges, and requires familiarity with species and individual responses. This narrative review describes the investigations into QST in clinical populations of dogs to date, and discusses the potential benefits and limitations of such testing. (C) 2018 Elsevier Ltd. All rights reserved.