A superparamagnetic polymersome with extremely high T2 relaxivity for MRI and cancer-targeted drug delivery
A superparamagnetic polymersome with extremely high T2 relaxivity for MRI and cancer-targeted drug delivery
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具有极高 T2 弛豫度的超顺磁性聚合物囊泡，适用于 MRI 和癌症靶向药物输送。
DOI：
10.1016/j.biomaterials.2016.10.027
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发表时间：
2017-01-01
期刊：
影响因子：
14
通讯作者：
Du, Jianzhong
中科院分区：
文献类型：
--
作者：
Liu, Qiuming;Song, Liwen;Du, Jianzhong
提高磁共振成像（MRI）造影剂的弛豫率是癌症治疗诊断学的一个重要挑战。本文报道了一种具有极高T-2弛豫率（611.6 mM（-1）s（-1））的新型MRI造影剂超顺磁性聚合物囊泡的设计、合成、表征、理论分析和体内试验。首先，基于可生物降解的二嵌段共聚物叶酸-聚（L-谷氨酸）-嵌段-聚（ε-己内酯）[FA-PGA-b-PCL]合成了无细胞毒性的癌症靶向聚合物囊泡。然后，超小超顺磁性氧化铁纳米粒子（SPION）在聚合物囊泡的亲水性PGA冠原位生成，得到磁性聚合物囊泡。在体内MRI分析显示，在非常低的Fe剂量为0.011 mmol/kg的磁性聚合物囊泡显着的负对比度增强。此外，这种癌症靶向磁性聚合物囊泡可以有效地包裹和递送抗癌药物，以抑制肿瘤生长，显示出在生物医学中的治疗诊断应用前景。(C)2016爱思唯尔有限公司版权所有。
Improving the relaxivity of magnetic resonance imaging (MRI) contrast agents is an important challenge for cancer theranostics. Herein we report the design, synthesis, characterization, theoretical analysis and in vivo tests of a superparamagnetic polymersome as a new MRI contrast agent with extremely high T-2 relaxivity (611.6 mM(-1)s(-1)). First, a noncytotoxic cancer-targeting polymersome is synthesized based on a biodegradable diblock copolymer, folic acid-poly(L-glutamic acid)-block-poly(epsilon-caprolactone) [FA-PGA-b-PCL]. Then, ultra-small superparamagnetic iron oxide nanoparticles (SPIONs) are in situ generated in the hydrophilic PGA coronas of polymersomes to afford magnetic polymersomes. The in vivo MRI assay revealed prominent negative contrast enhancement of magnetic polymersomes at a very low Fe dose of 0.011 mmol/kg. Moreover, this cancer-targeting magnetic polymersome can effectively encapsulate and deliver anticancer drug to inhibit the tumor growth, demonstrating promising theranostic applications in biomedicine. (C) 2016 Elsevier Ltd. All rights reserved.