Influence of vitamin D and estrogen receptor gene polymorphisms on calcium absorption: BsmI predicts a greater decrease during energy restriction.
Influence of vitamin D and estrogen receptor gene polymorphisms on calcium absorption: BsmI predicts a greater decrease during energy restriction.
复制标题
维生素 D 和雌激素受体基因多态性对钙吸收的影响：BsmI 预测能量限制期间钙吸收的下降幅度更大。
DOI：
10.1016/j.bone.2015.07.011
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发表时间：
2015
期刊：
影响因子：
4.1
通讯作者：
Shapses,SA
中科院分区：
文献类型：
--
作者：
Chang,B;Schlussel,Y;Sukumar,D;Schneider,SH;Shapses,SA
Low calcium absorption is associated with low bone mass and fracture. In this study, we use gold standard methods of fractional calcium absorption (FCA) to determine whether polymorphisms of intestinal receptors, vitamin D receptor (VDR) and estrogen receptor α (ESR1), influence the response to energy restriction. Fractional calcium absorption was measured using dual stable isotopes (42Ca and43Ca) in women given adequate calcium and vitamin D and examined at baseline and after 6 weeks of energy restriction or no intervention. After genotyping, the relationship betweenVDRandESR1genotypes/haplotypes and FCA response was assessed using several genetic models. One-hundred and sixty-eight women (53 ± 11 years of age) were included in this analysis. TheESR1polymorphisms,PvuII andXbaI andVDRpolymorphisms (TaqI,ApaI) did not significantly influence FCA. TheBBgenotype of theVDRpolymorphism,BsmI, was associated with a greater decrease in FCA than theBb/bbgenotype. Multiple linear regression showed that theBsmI polymorphism or theVDRhaplotype,BAt, in addition to changes in weight and vitamin D intake explained ~ 16% of the variation in changes in FCA. In conclusion, the reduction in calcium absorption due to energy restriction is greatest for those with theBBgenotype. Previous candidate gene studies show thatVDRpolymorphisms are associated with higher risk for osteoporosis, and the current study supports the notion that theBsmI polymorphism in intestinal VDR may be contributing to alterations in bone health.
