Dietary protein intake and upper leg muscle strength in subjects with knee osteoarthritis: data from the osteoarthritis initiative
Dietary protein intake and upper leg muscle strength in subjects with knee osteoarthritis: data from the osteoarthritis initiative
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DOI：
10.1007/s00296-018-4223-x
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发表时间：
2019-02-01
影响因子：
4
通讯作者：
Dekker, J.
中科院分区：
文献类型：
--
作者：
de Zwart, A. H.;van der Leeden, M.;Dekker, J.
本研究的目的是（1）描述膳食蛋白质摄入量，（2）评价膝骨关节炎（OA）受试者膳食蛋白质摄入量与大腿肌肉力量之间的关系。在一项横断面研究中使用了OA的基线数据。所有受试者均被诊断为有症状和影像学膝关节OA。每日膳食蛋白质摄入量用Block Brief 2000食物频率问卷（g/kg体重）测量。使用良好强度椅子测试评估索引膝关节的膝关节屈曲和伸展强度总和（N/kg体重）。线性回归分析用于检验膳食蛋白质摄入量与肌肉力量之间的关系，并对相关混杂因素进行调整。使用了1316例受试者的数据（平均年龄61.4 ± SD 9.1岁，57.0%为女性）。平均每日蛋白质摄入量为0.72 +/-SD 0.30 g/kg体重，65.1%的受试者的蛋白质摄入量低于推荐的每日允许量0.8 g/kg体重。平均肌力为5.4 +/-SD 2.1 N/kg体重。较低的蛋白质摄入量与较低的肌肉力量显著相关（B = 0.583，95% CI 0.230 - 0.936，p = 0.001）。大多数膝关节OA受试者的膳食蛋白质摄入量低于推荐的每日摄入量。较低的蛋白质摄入量与小腿肌肉力量有关。需要进行纵向观察性和干预性研究，以确定膳食蛋白质摄入量是否对膝关节OA受试者的肌肉力量有因果关系。
The aims of this study were (1) to describe dietary protein intake, and (2) to evaluate the association between dietary protein intake and upper leg muscle strength in subjects with knee osteoarthritis (OA). Baseline data from the OA was used, in a cross-sectional study. All subjects were diagnosed with symptomatic and radiographic knee OA. Daily dietary protein intake was measured with the Block Brief 2000 food frequency questionnaire (g/kg body weight). The sum of knee flexion and extension strength of the index knee (N/kg bodyweight) was assessed with the Good Strength chair test. Linear regression analysis was used to test the association between dietary protein intake and muscle strength, adjusting for relevant confounders. Data from 1316 subjects (mean age 61.4 +/- SD 9.1 years, 57.0% female) were used. The mean daily protein intake was 0.72 +/- SD 0.30 g/kg bodyweight, and 65.1% of the subjects had a protein intake lower than the recommended daily allowance of 0.8 g/kg bodyweight. The mean muscle strength was 5.4 +/- SD 2.1 N/kg bodyweight. Lower protein intake was significantly associated with lower muscle strength (B=0.583, 95% CI 0.230-0.936, p=0.001). The majority of the subjects with knee OA had a dietary protein intake lower than the recommended daily allowance. Lower protein intake was associated with lower upper leg muscle strength. Longitudinal observational and interventional studies are needed to establish whether dietary protein intake has a causal effect on muscle strength in subjects with knee OA.