Reproducibility of pattern electroretinogram in glaucoma patients with a range of severity of disease with the new glaucoma paradigm
Reproducibility of pattern electroretinogram in glaucoma patients with a range of severity of disease with the new glaucoma paradigm
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DOI：
10.1016/j.ophtha.2007.08.023
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发表时间：
2008-06-01
期刊：
影响因子：
13.7
通讯作者：
Feuer, William
中科院分区：
文献类型：
--
作者：
Fredette, Marie-Josee;Anderson, Douglas R.;Feuer, William
目的：用新的青光眼视网膜电图（PERGLA）记录范式确定不同严重程度青光眼患者视网膜电图的可重复性。设计：实验研究。参与者：研究招募了53名青光眼患者（平均年龄+/-标准差[SD]， 69 +/- 11岁）。静态自动视野测量的平均偏差（MD）全局指数为2.16 ~ -31.36分贝（平均MD为-9.05）。干预：所有患者均采用标准化PERGLA模式，由同一操作人员在5个不同的天内进行5次视网膜电图记录。主要观察指标：视网膜电图模式振幅（微伏）、相位（π弧度）、形成视网膜电图模式波形的2个部分平均值的振幅和相位的响应变异性（变异系数[CV] = SD/mean x 100）、眼间振幅和相位的不对称性（根据视网膜电图模式软件生成的CV）、信噪比（S/N）、SDs、CV和类内相关系数（ICC）。除了眼间不对称的研究外，所有的分析都是在每个受试者的一只眼睛上进行的。结果：种群内变异幅度和期变异cv分别为12.08%和2.20%，种群间变异cv分别为20.82%和4.17%。模式视网膜电图产生的间歇icc振幅为0.791，相为0.765。这些ICCs在振幅和相位上明显高于视网膜电图眼间不对称的ICCs (0.659 [P
Purpose: To determine the reproducibility of the pattern electroretinogram with the new Pattern Electroretinogram for Glaucoma (PERGLA) recording paradigm in glaucoma patients with a range of severity.Design: Experimental study.Participants: Fifty-three glaucoma patients were recruited for the study (mean age +/- standard deviation [SD], 69 +/- 11 years). Their mean deviation (MD) global indices on static automatic perimetry ranged from 2.16 to -31.36 decibels (mean MD, -9.05).Intervention: All patients had pattern electroretinogram recordings done 5 times by the same operator, on 5 different days with the standardized PERGLA paradigm.Main Outcome Measures: Pattern electroretinogram amplitude (microvolts), phase (pi radians), response variability (coefficient of variation [CV] = SD/mean x 100) of amplitude and phase of 2 partial averages that build up the pattern electroretinogram waveform, interocular asymmetry in amplitude and phase (in terms of the CV generated by the pattern electroretinogram software), signal-to-noise (S/N) ratio, SDs, CV, and intraclass correlation coefficient (ICC). All analyses were done on one eye of each subject, except when interocular asymmetry was studied.Results: The CVs of intrasession variabilities in amplitude and phase were 12.08% and 2.20%, respectively, and those of intersession variabilities were 20.82% and 4.17%. The pattern electroretinogram produced intersession ICCs in amplitude and phase of 0.791 and 0.765, respectively. These ICCs were significantly higher than the ICCs for pattern electroretinogram interocular asymmetry in amplitude and phase (0.659 [P