CMR-derived extracellular volume fraction (ECV) in asymptomatic heart transplant recipients: correlations with clinical features and myocardial edema
CMR-derived extracellular volume fraction (ECV) in asymptomatic heart transplant recipients: correlations with clinical features and myocardial edema
复制标题
无症状心脏移植受者中 CMR 衍生的细胞外体积分数 (ECV)：与临床特征和心肌水肿的相关性
DOI：
10.1007/s10554-018-1421-2
复制
发表时间：
2018-07
影响因子：
2.1
通讯作者：
Bo Liang
中科院分区：
文献类型：
--
作者：
Yating Yuan;Jie Cai;Yue Cui;Jing Wang;Osamah Alwalid;Xuehua Shen;Yukun Cao;Yan Zou;Bo Liang
心肌间质扩张似乎是不良左心室重构过程的基础。最近的证据表明，源自心血管磁共振 (CMR) 的细胞外体积分数 (ECV) 可用作量化一系列心脏病中心肌间质体积的无创方法。我们的目的是确定无症状原位心脏移植 (HTx) 患者的 ECV 是否升高及其与临床特征和 T2 值的关系，T2 值升高通常提示心肌水肿。 2017 年 3 月至 6 月，一组无症状心脏移植受者和一些健康志愿者被邀请接受全面的 CMR 扫描，包括电影成像、晚期钆增强、T1 映射和 T2 映射。所有定量测量结果均取基底和中短轴切片的平均值。 HTx 后平均年龄为 1.8 年（0.3-6.3 年）的 58 名接受者（平均年龄 42.7±11.5 岁；13 名女性）和 20 名健康志愿者（平均年龄 39.5±11.3 岁；5 名女性）接受了 CMR 扫描。我们发现 HTx 组的 ECV 和 T2 值均较高（ECV：26.7±±3.3 vs. 24.6±±2.5%，p=±0.008；T2：47.7±±2.8 vs. 44.5±±1.6 ms， p < 0.001) 高于对照组。 ECV 与移植时的器官缺血时间中度相关，但与血流动力学参数或 CMR 移植后的时间无关。此外，ECV 和 T2 之间观察到相对较强的相关性（r = 0.7，p < 0.001）。因此，我们的结论是，CMR 衍生的 ECV 增加，并且与无症状 HTx 患者的围移植缺血时间相关。 ECV与T2升高的强相关性表明心肌水肿可能是心脏移植后细胞外容量扩张的重要组成部分。
Myocardial interstitial expansion seems to be fundamental to the process of adverse left ventricular remodeling. Recent evidence has shown that the extracellular volume fraction (ECV) derived from cardiovascular magnetic resonance (CMR) can be used as a noninvasive method to quantify myocardial interstitial volume in a range of heart diseases. Our aim was to determine whether ECV is increased in asymptomatic orthotopic heart transplant (HTx) patients and its associations with clinical features and T2 values, the elevation of which usually suggests myocardial edema. A group of asymptomatic cardiac transplant recipients and some healthy volunteers were invited to undergo a comprehensive CMR scan, including cine imaging, late gadolinium enhancement, T1 mapping and T2 mapping, from March to June in 2017. All quantitative measurements were averaged from the basal and mid short-axis slices. Fifty-eight recipients (mean age, 42.7 ± 11.5 years; 13 females), at a median of 1.8 years (0.3–6.3 years) after HTx, and 20 healthy volunteers (mean age, 39.5 ± 11.3 years; 5 females) underwent the CMR scan. We found that both the ECV and T2 values were higher in the post-HTx group (ECV: 26.7 ± 3.3 vs. 24.6 ± 2.5%, p = 0.008; T2: 47.7 ± 2.8 vs. 44.5 ± 1.6 ms, p < 0.001) than in the control group. ECV was moderately associated with organ ischemia time at the time of transplantation but not with the hemodynamics parameter or the time since transplantation at CMR. Additionally, a relatively strong correlation was observed between ECV and T2 (r = 0.7, p < 0.001). So, our conclusion is that CMR-derived ECV is increased and associated with peri-transplant ischemia time in asymptomatic HTx patients. And the strong correlation of ECV with elevated T2 indicates that myocardial edema may be an important part of the extracellular volume expansion after heart transplantation.
登录
查看更多内容
影响因子：
6.4
作者：
Miller CA;Sarma J;Naish JH;Yonan N;Williams SG;Shaw SM;Clark D;Pearce K;Stout M;Potluri R;Borg A;Coutts G;Chowdhary S;McCann GP;Parker GJ;Ray SG;Schmitt M
通讯作者：
Schmitt M
DOI：
10.1186/s12968-014-0052-6
发表时间：
2014-07-20
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Miller CA;Naish JH;Shaw SM;Yonan N;Williams SG;Clark D;Bishop PW;Ainslie MP;Borg A;Coutts G;Parker GJ;Ray SG;Schmitt M
通讯作者：
Schmitt M
影响因子：
24
作者：
Miller, Christopher A.;Sarma, Jaydeep;Schmitt, Matthias
通讯作者：
Schmitt, Matthias
影响因子：
7.5
作者：
Miller, Christopher A.;Naish, Josephine H.;Schmitt, Matthias
通讯作者：
Schmitt, Matthias
影响因子：
19.7
作者：
Sibley, Christopher T.;Noureldin, Radwa A.;Bluemke, David A.
通讯作者：
Bluemke, David A.