Cerebral blood flow is reduced in chronic fatigue syndrome as assessed by arterial spin labeling
Cerebral blood flow is reduced in chronic fatigue syndrome as assessed by arterial spin labeling
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DOI：
10.1016/j.jns.2010.11.018
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发表时间：
2011-02-15
影响因子：
4.4
通讯作者：
Natelson, Benjamin H.
中科院分区：
文献类型：
--
作者：
Biswal, Bharat;Kunwar, Pratap;Natelson, Benjamin H.
背景：慢性疲劳综合征的诊断有一套临床标准，因此可能是异质性的。早期的报告通过研究脑血流量（CBF）来验证该综合征具有神经学基质的假设，但结果不一致。差异的一个可能原因是评估了相对CBF。我们发现减少CBF的绝对CBF使用氙CT的早期研究。本研究的目的是使用第二种方法评估CBF和研究组内的异质性respons.Method：11 CFS患者和10名年龄匹配的健康对照进行神经影像学使用动脉自旋标记，以确定其区域和全球的绝对CBF。一个模板的基础上构建的控制数据，和个别患者的蒙太奇进行了比较，在个案的基础上，以确定是否在感兴趣的区域的差异occurrent.Results：作为一个组的患者有显着降低全球CBF比对照组。CBF的减少几乎发生在评估的每个地区。11例患者中有9例显示这些减少相比，平均控制数据，而两名患者表现出实际增加相对于controls.Conclusion：数据扩展了我们早期的观察，CFS患者作为一个群体有广泛的CBF下降相比，健康对照。然而，正如预期的那样，效果并不均匀，研究的11例患者中有2例显示CBF相对于对照组实际增加。(C)2010爱思唯尔有限公司版权所有。
Background: Chronic fatigue syndrome is diagnosed by a set of clinical criteria and therefore is probably heterogeneous. Earlier reports tested the hypothesis that the syndrome had a neurological substrate by doing studies of cerebral blood flow (CBF) but with discrepant results. One possible reason for the discrepancy was that relative CBF was assessed. We found reduced CBF in an earlier study of absolute CBF using xenon-CT. The purpose of this study was to use a second method of assessing CBF and to look within the study group for heterogeneity of responses.Method: Eleven CFS patients and 10 age matched healthy controls underwent neuroimaging using arterial spin labeling to determine their regional and global absolute CBF. A template was constructed based on the control data, and individual patient montages were compared on a case by case basis to determine if differences in regions of interest occurred.Results: The patients as a group had significantly lower global CBF than the controls. The reduction in CBF occurred across nearly every region assessed. Nine of the 11 patients showed these reductions compared to the average control data, while two patients showed actual increases relative to the controls.Conclusion: The data extend our earlier observation that CFS patients as a group have broad decreases in CBF compared to healthy controls. However, as expected, the effect was not homogeneous in that 2 of the 11 patients studied showed actual increases in CBF relative to controls. (C) 2010 Elsevier B.V. All rights reserved.