Serologic Markers for Detecting Malaria in Areas of Low Endemicity, Somalia, 2008
Serologic Markers for Detecting Malaria in Areas of Low Endemicity, Somalia, 2008
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DOI：
10.3201/eid1603.090732
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发表时间：
2010-03-01
影响因子：
11.8
通讯作者：
Drakeley, Chris
中科院分区：
文献类型：
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作者：
Bousema, Teun;Youssef, Randa M.;Drakeley, Chris
疟疾不是高度流行的地区适合消灭疟疾，但由于常用方法缺乏敏感性，很难评估传播情况。我们评估了检测索马里疟疾暴露变异的血清学标志物。在旱季(0/1,178)和雨季(0/1,128)对人群样本的横断面调查中，显微镜未检出恶性疟原虫或间日疟原虫。对恶性疟原虫和间日疟原虫的抗体反应率分别为17.9%(179/1,001)和19.3%(202/1,044)。3个村间对恶性疟原虫的反应性差异有统计学意义(P
Areas in which malaria is not highly endemic are suitable for malaria elimination, but assessing transmission is difficult because of lack of sensitivity of commonly used methods. We evaluated serologic markers for detecting variation in malaria exposure in Somalia. Plasmodium falciparum or P. vivax was not detected by microscopy in cross-sectional surveys of samples from persons during the dry (0/1,178) and wet (0/1,128) seasons. Antibody responses against P falciparum or P. vivax were detected in 17.9% (179/1,001) and 19.3% (202/1,044) of persons tested. Reactivity against P falciparum was significantly different between 3 villages (p