Morphologic Changes Associated with Intrathecal Catheters for Direct Delivery to the Central Nervous System in Preclinical Studies
Morphologic Changes Associated with Intrathecal Catheters for Direct Delivery to the Central Nervous System in Preclinical Studies
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DOI：
10.1177/0192623310391679
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发表时间：
2011-01-01
影响因子：
1.5
通讯作者：
Butt, Mark T.
中科院分区：
文献类型：
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作者：
Butt, Mark T.
对猴、犬、绵羊和大鼠鞘内研究中对照（器械和/或生理盐水处理）动物的显微镜评价数据进行了回顾性分析。这些研究由多个试验机构进行。所有载玻片制备和显微镜评价均在作者的实验室进行。这些数据是在导管头端水平进行的观察，导管头端通常位于椎管胸腰椎区域附近的鞘内空间。对照动物中最常见的显微镜检查变化为脑膜浸润、导管道（CT）炎症、脊髓压迫（CT处）、CT纤维化、脊髓胶质增生（CT处）和脊髓神经纤维变性。尽管研究之间存在差异（甚至在种属内），但一般而言，对照动物中这些发现的平均严重程度极轻微或更低。在25只对照犬中的3只和77只对照猴中的2只中观察到CT炎性肿块/脓肉芽肿形成，这是以较高浓度/剂量给予吗啡后的已知并发症。这些数据表明，对照动物中可能发生炎性肿块/脓肉芽肿形成，与猴、绵羊和大鼠相比，犬中最常见。
A retrospective analysis of microscopic evaluation data from control (device and/or saline-treated) animals in intrathecal studies in monkeys, dogs, sheep, and rats was conducted. The studies were performed by multiple testing facilities. All slide preparation and microscopic evaluation were conducted in the laboratory of the author. The data were of observations made at the level of the catheter tip, which typically was located in the intrathecal space near the thoracolumbar region of the spinal canal. The most common microscopic changes in control animals were meningeal infiltrates, catheter track (CT) inflammation, spinal cord compression (at the CT), CT fibrosis, spinal cord gliosis (at the CT), and spinal cord nerve fiber degeneration. Although variable between studies (even within species), in general the average severity of these findings was minimal or less in control animals. CT inflammatory mass/pyogranuloma formation, a known complication following the administration of morphine at higher concentrations/doses, was noted in 3 of 25 control dogs and 2 of 77 control monkeys. These data show that inflammatory mass/pyogranuloma formation may occur in control animals, and this occurrence is most common in dogs as compared to monkeys, sheep, and rats.