Oh, the places they'll go! A survey of phytopathogen effectors and their host targets
Oh, the places they'll go! A survey of phytopathogen effectors and their host targets
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DOI：
10.1111/tpj.13780
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发表时间：
2018-02-01
期刊：
影响因子：
7.2
通讯作者：
Desveaux, Darrell
中科院分区：
文献类型：
--
作者：
Khan, Madiha;Seto, Derek;Desveaux, Darrell
植物病原体将效应蛋白转运到植物细胞中，在那里它们破坏宿主细胞机制以促进感染。单个病原体可以在感染过程中易位许多不同的效应物，以靶向一系列宿主大分子（蛋白质、代谢物、DNA等）。并利用各种酶活性来操纵它们。在这篇综述中，我们已经调查了文献的效应靶点，并策划他们传达植物病原蛋白在宿主细胞内进行的功能范围。特别是，我们策划了效应靶点的位置，以及它们的生物学和分子功能，并在不同的植物病原体中比较了这些特性。这种分析验证了以前的观察效应功能（如免疫抑制），也突出了一些有趣的功能，效应特异性以及功能多样化的植物病原体毒力策略。
Phytopathogens translocate effector proteins into plant cells where they sabotage the host cellular machinery to promote infection. An individual pathogen can translocate numerous distinct effectors during the infection process to target an array of host macromolecules (proteins, metabolites, DNA, etc.) and manipulate them using a variety of enzymatic activities. In this review, we have surveyed the literature for effector targets and curated them to convey the range of functions carried out by phytopathogenic proteins inside host cells. In particular, we have curated the locations of effector targets, as well as their biological and molecular functions and compared these properties across diverse phytopathogens. This analysis validates previous observations about effector functions (e.g. immunosuppression), and also highlights some interesting features regarding effector specificity as well as functional diversification of phytopathogen virulence strategies.