One step from nitro to oxime: a convenient preparation of unsaturated oximes by the reduction of the corresponding vinylnitro compounds
One step from nitro to oxime: a convenient preparation of unsaturated oximes by the reduction of the corresponding vinylnitro compounds
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从硝基到肟的一步：通过还原相应的乙烯基硝基化合物方便地制备不饱和肟
DOI：
10.1016/j.tet.2009.10.042
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发表时间：
2009-12-12
期刊：
影响因子：
2.1
通讯作者：
Cui, Jingnan
中科院分区：
文献类型：
--
作者：
Wang, Kewei;Qian, Xuhong;Cui, Jingnan
通过用 SnCl2 中心点 2H(2)O 还原相应的乙烯基硝基化合物，可以方便地制备一系列新型不饱和肟。通过H-1和C-13 NMR、IR和HRMS对肟的结构进行了表征，1-(6-氯-吡啶-3-基甲基)-4,5-二氢-1H-咪唑-2-甲醛肟2a的X射线晶体分析表明，羟基以反式构型排列。简短调查的一些证据表明，这些肟似乎是通过还原硝基脂肪族化合物的酸形式而形成的。 (C) 2009 Elsevier Ltd. 保留所有权利。
A series of novel unsaturated oximes were conveniently prepared from the corresponding vinylnitro compounds by reduction with SnCl2 center dot 2H(2)O. The structures of the oximes were characterized by H-1 and C-13 NMR, IR and HRMS, and X-ray crystallography analysis of 1-(6-chloro-pyridin-3-ylmethyl)-4,5-dihydro-1H-imidazole-2-carbaldehyde oxime 2a reveals that, the hydroxyl group is arranged in a trans configuration. Some evidences from a brief investigation suggest that these oximes seem to be formed by reduction of the aci form of nitro aliphatic compounds. (C) 2009 Elsevier Ltd. All rights reserved.