Independent codes for spatial and episodic memory in hippocampal neuronal ensembles
Independent codes for spatial and episodic memory in hippocampal neuronal ensembles
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DOI：
10.1126/science.1114037
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发表时间：
2005-07-22
期刊：
影响因子：
56.9
通讯作者：
Moser, MB
中科院分区：
文献类型：
--
作者：
Leutgeb, S;Letugeb, JK;Moser, MB
在记录室变化但其位置保持不变的条件下记录海马神经元，而在不同位置遇到相同室的条件下记录海马神经元。发生了两种形式的神经元模式分离。在可变线索恒定位置条件下，活性细胞的放电率发生变化，通常超过一个数量级，而放电位置保持不变。在可变位置恒定提示条件下，位置和速率都发生变化，因此室内给定位置的群体向量在统计上是独立的。这些独立的编码方案可以实现空间和情景记忆信息的同时表示。
Hippocampal neurons were recorded under conditions in which the recording chamber was varied but its location remained unchanged versus conditions in which an identical chamber was encountered in different places. Two forms of neuronal pattern separation occurred. In the variable cue-constant place condition, the firing rates of active cells varied, often over more than an order of magnitude, whereas the location of firing remained constant. In the variable place-constant cue condition, both location and rates changed, so that population vectors for a given location in the chamber were statistically independent. These independent encoding schemes may enable simultaneous representation of spatial and episodic memory information.