A concise synthetic approach to parvistemin A and (+/-)-diperezone
A concise synthetic approach to parvistemin A and (+/-)-diperezone
复制标题
parvistemin A 和 (/-)-diperezone 的简明合成方法
DOI：
10.1039/c7qo00216e
复制
发表时间：
2017
影响因子：
5.4
通讯作者：
Hu Xiangdong
中科院分区：
文献类型：
--
作者：
Gao Songsong;Hu Xiangdong
以K3[Fe（CN）6]或FeCl 3为氧化剂，在碱性条件下，通过1，2，4-三羟基芳烃的仿生氧化酚偶联反应，发展了一种合成对称联醌骨架的简便方法。结合环丁烯酮的扩环反应，提出了一种合成双醌类天然产物的方法。在此基础上，实现了小菊素A和（±）-双哌酮的全合成。
A concise synthetic approach to symmetric biquinone skeletons has been developed through a new biomimetic oxidative phenolic coupling of 1,2,4-trihydroxyarenes using K3[Fe(CN)6] or FeCl3 as the oxidant under basic conditions. Merging with the ring expansion process of cyclobutenones, a synthetic strategy to biquinone natural products has been developed. And in the light of this strategy, total syntheses of parvistemin A and (±)-diperezone have been achieved.