Preparation of chronic lung lymph fistulas in sheep.
Preparation of chronic lung lymph fistulas in sheep.
复制标题
绵羊慢性肺淋巴瘘的制备。
DOI：
10.1016/0022-4804(75)90056-6
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
W. Woolverton
中科院分区：
文献类型：
--
作者：
N. Staub;R. Bland;K. Brigham;R. Demling;A. Erdmann;W. Woolverton
绵羊肺淋巴大部分通过一个大的尾部纵隔淋巴结排出。在初步手术中，我们会清除全身淋巴污染。我们通过穿刺淋巴结的传出管来获得肺淋巴。我们使用生理测试，分别提高全身和肺静脉压力，以表明淋巴的来源是肺。在超过1周的时间内获得肺淋巴流的总体成功率小于50%。成功的动物是研究净肺液和蛋白流的优秀模型。
The majority of lung lymph in the sheep drains through a large caudal mediastinal lymph node. At a preliminary operation, we remove the systemic lymph contamination. We obtain lung lymph by cannulating the efferent duct of the node. We use a physiologic test in which we elevate systemic and pulmonary venous pressures separately to show that the origin of the lymph is from the lung. The overall success rate in obtaining lung lymph flow for periods longer than 1 week is less than 50%. Successful animals are excellent models in which to study net lung fluid and protein flow.