Are ion-exchange processes central to understanding drug-resistance phenomena?
Are ion-exchange processes central to understanding drug-resistance phenomena?
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离子交换过程是理解耐药现象的核心吗？
DOI：
10.1016/s0165-6147(98)01282-6
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发表时间：
1999
影响因子：
13.8
通讯作者：
Martiney,JA
中科院分区：
文献类型：
--
作者：
Roepe,PD;Martiney,JA
Drug resistance in malarial parasites is arguably the greatest challenge currently facing infectious disease research. In addressing this problem, researchers have been intrigued by similarities between drug-resistant malarial parasites and tumour cells. For example, it was originally thought that the role of pfMDR (Plasmodium falciparummultidrug resistance) proteins was central in conferring antimalarial multidrug resistance. However, recent work has questioned the precise role of MDR proteins in multidrug resistance. In addition, recent ground-breaking work in identifying mutations associated with antimalarial drug resistance might have led to identification of yet another parallel between drug-resistant tumour cells and malarial parasites, namely, intriguing alterations in transmembrane ion transport, discussed here byPaul Roepe and James Martiney. This further underscores an emerging paradigm in drug-resistance research.
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DOI：
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发表时间：
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期刊：
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影响因子：
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