Closed-loop deep brain stimulation based on firing-rate regulation
Closed-loop deep brain stimulation based on firing-rate regulation
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基于放电率调节的闭环深部脑刺激
DOI：
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
E. Panteley
中科院分区：
文献类型：
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作者：
W. Pasillas;Ihab Haidar;A. Chaillet;E. Panteley
本文开发了一种新的闭环式脑深部刺激策略，该策略基于对基底节的基于模型的分析。为了分析β-带振荡的产生，用最近文献中提出的发射率模型来描述该系统。在这个系统上，对放电频率的比例调节补偿了帕金森病患者丘脑-苍白球下部环路的稳定性损失。然而，由于刺激装置中的激励和测量延迟，必须在这种比例方案中添加具有适当选择的频率的滤波器，以便获得足够的稳定裕度。
This paper develops a new closed-loop strategy for deep brain stimulation, derived using a model-based analysis of the basal ganglia. The system is described using a firing-rate model that has been proposed recently in the literature, in order to analyze the generation of beta-band oscillations. On this system, a proportional regulation of the firing-rate compensates the loss of stability of the subthalamo-pallidal loop in the parkinsonian case. Nevertheless, because of actuation and measurement delays in the stimulation device, a filter with a well chosen frequency must be added to such proportional schemes, in order to achieve an adequate stability margin.