POSSIBLE CONSEQUENCES OF ELIMINATION DIETS IN ASYMPTOMATIC IMMEDIATE HYPERSENSITIVITY TO FISH
POSSIBLE CONSEQUENCES OF ELIMINATION DIETS IN ASYMPTOMATIC IMMEDIATE HYPERSENSITIVITY TO FISH
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DOI：
10.1111/j.1398-9995.1992.tb00670.x
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发表时间：
1992-10-01
期刊：
影响因子：
12.4
通讯作者：
PENA, JMD
中科院分区：
文献类型：
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作者：
LARRAMENDI, CH;ESTEBAN, MM;PENA, JMD
IgE抗体对食物的自然史没有相关症状是未知的。我们跟踪了7名患有各种特应性疾病和无症状的鱼类速发型超敏反应的儿童的进展，尽管他们对食物完全耐受，但仍采用消除饮食治疗。在24至113个月的饮食期间，所有7名患者在意外暴露于鱼或用鱼进行激发试验后立即出现症状（所有7例皮肤症状，5例消化道症状，4例呼吸道症状和2例过敏反应），这些症状与先前存在的特应性疾病相关症状不同。鱼特异性IgE水平（点刺试验，RAST）保持不变或增加。这些发现表明，在消除饮食期间，可能由于与过敏原的最小和隐藏的接触，患者的致敏程度可能会增加，将无症状变为有症状的速发型超敏反应。
The natural history of IgE antibodies to food without related symptoms is unknown. We have followed the progress of 7 children with various atopic diseases and asymptomatic immediate hypersensitivity to fish, treated with elimination diet in spite of full alimentary tolerance. During the diet period, between 24 and 113 months, all 7 patients presented immediate symptoms upon accidental exposure to or challenge tests with fish (skin symptoms in all 7 cases, digestive in 5, respiratory in 4, and anaphylaxis in 2), which differed from those related to atopic diseases previously present. The levels of fish-specific IgE (prick test, RAST) remained unchanged or were increased. These findings suggest that during elimination diet, and perhaps due to minimal and hidden contact with the allergen, the patients' degree of sensitization may increase, turning an asymptomatic into a symptomatic immediate hypersensitivity.