Serosorting for hepatitis C status in the sharing of injection equipment among Seattle area injection drug users
Serosorting for hepatitis C status in the sharing of injection equipment among Seattle area injection drug users
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DOI：
10.1016/j.drugalcdep.2009.07.005
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发表时间：
2009-12-01
影响因子：
4.2
通讯作者：
Hagan, Holly
中科院分区：
文献类型：
--
作者：
Burt, Richard D.;Thiede, Hanne;Hagan, Holly
背景：丙型肝炎病毒（HCV）是注射吸毒者（IDU）的主要健康问题。降低丙型肝炎病毒在注射吸毒者之间传播风险的一种潜在手段是血清分选，即注射吸毒者优先与丙型肝炎病毒状况相似的人共用注射设备。方法：2005年，作为国家HIV/AIDS行为监测系统的一部分，我们对西雅图地区IDU进行了问卷调查。结果：在337名参与者中，91%的人报告曾接受过HCV检测。在过去12个月内共用任何注射设备的参与者中，有53%的人报告说，他们知道与他们共用注射设备的最后一个人的丙型肝炎病毒状况。在自我报告的丙型肝炎病毒阳性参与者中，37%的人报告说，他们最后一个共用注射设备的伴侣也是丙型肝炎病毒阳性，7%的人报告说有一个丙型肝炎病毒阴性的伴侣。在自我报告丙型肝炎病毒阴性的参与者中，11%报告有丙型肝炎病毒阳性的伴侣，23%报告有丙型肝炎病毒阴性的伴侣。在分层和逻辑回归分析中，在控制了与丙型肝炎病毒阳性相关的特征后，与丙型肝炎病毒状况相似的伴侣共用注射设备的不成比例倾向仍然存在。在共享注射设备的参与者中，39%的人报告说，他们在知道自己的丙型肝炎病毒状况的基础上故意与伴侣共享注射设备。结论：我们的结论是，西雅图地区IDU中出现了可测量程度的HCV状态血清分选。促进丙型肝炎病毒阳性注射吸毒者的血清分类可能是一种有用的减少危害的策略，这些注射吸毒者继续实行共用注射设备。如果判断有效，血清分选将为鼓励和支持在注射吸毒者中进行丙型肝炎病毒检测提供进一步的理由。2009爱思唯尔爱尔兰有限公司版权所有。
Background: Hepatitis C virus (HCV) is a major health problem among injection drug users (IDU). One potential means of reducing risk of HCV transmission among IDU is serosorting, whereby IDU preferentially share injection equipment with persons of like HCV status.Methods: We surveyed Seattle area IDU recruited by respondent-driven sampling as part of the National HIV/AIDS Behavioral Surveillance system in 2005.Results: Of 337 participants, 91% reported ever having been tested for HCV. Fifty-three percent of participants who shared any injection equipment in the last 12 months reported knowing the HCV status of the last person with whom they shared injection equipment. Thirty-seven percent of self-reported HCV-positive participants reported that their last injection equipment sharing partner was also HCV-positive and 7% reported a HCV-negative partner. Among self-reported HCV-negative participants, 11% reported a HCV-positive partner and 23% a negative partner. The disproportionate tendency to share injection equipment with a partner of like HCV status persisted after control for characteristics associated with HCV positivity in stratified and logistic regression analyses. Among participants sharing injection equipment, 39% reported that they had intentionally shared injection equipment with a partner based on knowledge of their concordant HCV status.Conclusions: We conclude that a measurable degree of serosorting by HCV status is occurring among Seattle area IDU. Promotion of serosorting among HCV-positive IDU may be a useful harm reduction strategy for IDU who continue to practice sharing injection equipment. If judged efficacious, serosorting would provide a further rationale to encourage and support HCV testing among IDU. (C) 2009 Elsevier Ireland Ltd. All rights reserved.