Cancer Health Literacy and Willingness to Participate in Cancer Research and Donate Bio-Specimens
Cancer Health Literacy and Willingness to Participate in Cancer Research and Donate Bio-Specimens
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DOI：
10.3390/ijerph15102091
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发表时间：
2018-10-01
影响因子：
--
通讯作者：
Serrano, Friar Sergio A.
中科院分区：
文献类型：
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作者：
Echeverri, Margarita;Anderson, David;Serrano, Friar Sergio A.
虽然它已被充分证明，穷人的健康素养与有限的参与癌症临床试验，研究评估癌症健康素养（CHL）和参与研究之间的关系在不同人群中缺乏。在这项研究中，我们研究了CHL和参与癌症研究和/或捐赠生物标本（WPRDB）的意愿之间的关系在非洲裔美国人，拉丁美洲人和白人。参与者完成了癌症健康素养测试和多维癌症素养问卷。计算总量表和子量表评分、频率、平均值和分布。采用方差分析、Bonferroni程序和霍尔姆方法检验组间的显著性差异。Cronbach’s alphas估计量表的内部一致性信度。在WPRDB量表和子量表评分上，发现种族/民族、性别和CHL之间存在显著的相互作用，即使在考虑了教育和年龄之后也是如此。我们的研究证实，CHL起着重要的作用，应该考虑和进一步研究。大多数参与者更愿意参与非侵入性研究（调查，访谈和培训）或生物标本（唾液，检查细胞，尿液和血液）的收集以及由他们自己的医疗保健提供者，当地医院和大学领导的研究。然而，参与者不太愿意参加更具侵入性的研究，要求他们服用药物，接受医疗程序或捐赠皮肤/组织。我们的结论是，解决低水平的CHL和使用基于社区的参与式方法来解决不同人群之间缺乏对癌症研究的知识和信任，不仅可以增加他们参与研究和捐赠生物标本的意愿，而且还可能对实际参与率产生积极影响。
Although it has been well documented that poor health literacy is associated with limited participation in cancer clinical trials, studies assessing the relationships between cancer health literacy (CHL) and participation in research among diverse populations are lacking. In this study, we examined the relationship between CHL and willingness to participate in cancer research and/or donate bio-specimens (WPRDB) among African Americans, Latinos, and Whites. Participants completed the Cancer Health Literacy Test and the Multidimensional Cancer Literacy Questionnaire. Total-scale and subscale scores, frequencies, means, and distributions were computed. Analyses of variance, the Bonferroni procedure, and the Holm method were used to examine significant differences among groups. Cronbach's alphas estimated scales' internal consistency reliability. Significant interactions were found between race/ethnicity, gender, and CHL on WPRDB scales and subscale scores, even after education and age were taken into account. Our study confirms that CHL plays an important role that should be considered and researched further. The majority of participants were more willing to participate in non-invasive research studies (surveys, interviews, and training) or collection of bio-specimens (saliva, check cells, urine, and blood) and in studies led by their own healthcare providers, and local hospitals and universities. However, participants were less willing to participate in more-invasive studies requiring them to take medications, undergo medical procedures or donate skin/tissues. We conclude that addressing low levels of CHL and using community-based participatory approaches to address the lack of knowledge and trust about cancer research among diverse populations may increase not only their willingness to participate in research and donate bio-specimens, but may also have a positive effect on actual participation rates.