A microRNA expression signature as a predictor of survival for colon adenocarcinoma
A microRNA expression signature as a predictor of survival for colon adenocarcinoma
复制标题
microRNA 表达特征作为结肠腺癌生存的预测因子
DOI：
10.4149/neo_2017_107
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发表时间：
2017-01-01
期刊：
影响因子：
3
通讯作者：
Yang, Q.
中科院分区：
文献类型：
--
作者：
Xu, M.;Kuang, Y.;Yang, Q.
结肠癌是全世界癌症死亡的主要原因，并且大多数结肠癌是腺癌。MicroRNA（miRNA）表达特征已被证明能够预测各种癌症的进展和预后。本研究的目的是探索一种新的microRNA表达标记来预测结肠腺癌患者的生存率。通过分析329例结肠腺癌患者的miRNA表达谱和临床信息，从癌症基因组图谱数据库中获得。129个miRNAs在癌组织和癌旁组织中有差异表达。其中27个miRNAs与患者相应的临床特征相关。此外，发现7种miRNAs（let-7a-2、mir-32、mir-181 a-1、mir-197、mir-328、mir-505和mir-652）与患者生存显著相关。我们建立的7-miRNA标签所确定的风险被证明是一个独立的预后因素（风险比[HR] = 2.048; 95%CI = 1.144-3.664; p，0.016）。总之，我们的研究确定了与结肠腺癌进展和预后相关的miRNA，并建立了预测结肠腺癌患者生存的7-microRNA表达特征。
Colon cancer is a major cause of cancer mortality worldwide and most colon cancers are adenocarcinoma. MicroRNA (miRNA) expression signature has been shown to be able to predict progression and prognosis of various cancers. The aim of our study was to explore a novel signature of microRNA expression for predicting survival of colon adenocarcinoma patients. By analyzing the miRNA expression profiles and clinical information of 329 colon adenocarcinoma patients derived from The Cancer Genome Atlas database. 129 miRNAs were identified to be expressed differentially between the cancer and adjacent tissues. Among them, 27 miRNAs were found to be associated with the corresponding clinical characteristics of the patients. Furthermore, 7 miRNAs (let-7a-2, mir-32, mir-181a-1, mir-197, mir-328, mir-505 and mir-652) were found to be significantly correlated with the patient survival. The risk established by the 7-miRNA signature we built was proved be an independent prognostic factor (Hazard ratio [HR] = 2.048; 95% CI = 1.144-3.664; p, 0.016). In summary, our study identified miRNAs correlated with progression and prognosis of colon adenocarcinoma and built a 7-microRNA expression signature for prediction of the survival of the patients with colon adenocarcinoma.