Database of Operons in Bacillus subtilis
Database of Operons in Bacillus subtilis
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枯草芽孢杆菌操纵子数据库
DOI：
10.11234/gi1990.13.496
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
M. Kanehisa
中科院分区：
文献类型：
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作者：
Shujiro Okuda;S. Kawashima;M. Kanehisa
操纵子是原核生物的一个转录单位，是复杂的基因调控网络的一部分。因此，几个实验室已经对操纵子进行了预测[1,2,4]。然而，为了验证预测方法，需要一个已知操作子的数据库，其中包含有关实际转录单元和转录条件的附加信息。在大肠杆菌中，已开发出RegulonDB[2]，它整合了操纵子、调控子、启动子、终止子等生物学知识[3]，使研究能够验证预测操纵子。相比之下，尚未建立枯草芽孢杆菌的操纵子数据库。因此，我们已经开始在文献和实验中组织有关操作子和转录单位的信息。
The operon, a unit of transcription in prokaryotes, comprises a part of the complicated gene regulatory networks. Thus, the prediction of operons has been carried out at several laboratories [1, 2, 4]. However, for validation of the prediction method, a database of known operons is required with additional information about actual transcriptional units and the conditions when they are transcribed. In Escherichia coli, the RegulonDB [2] have been developed, which integrates biological knowledge on operons, regulons, promoters, terminators and so on [3], enabling researches to validate prediction operons. In contrast, an operon database of B. subtilis has not been developed. Hence, we have initiated organizing the information about operons and transcriptional units in literature and also in experiments.