Regional localization of the TIMP gene on the human X chromosome
Regional localization of the TIMP gene on the human X chromosome
复制标题
TIMP基因在人类X染色体上的区域定位
DOI：
10.1007/bf00278995
复制
发表时间：
1989
期刊：
影响因子：
5.3
通讯作者：
B. Williams
中科院分区：
文献类型：
--
作者：
Huntington F. Willard;Sharon J. Durfy;M. Mahtani;Huw Dorkins;Kay E. Davies;B. Williams
编码金属蛋白酶组织抑制剂TIMP的基因先前已被证明在人类和小鼠基因组中都是x连锁的。我们使用了一系列分离易位和缺失X染色体的体细胞杂交来绘制人类X染色体上的timpgene。结合以往的数据，该基因可以被分配到Xp11.23→Xp11.4。遗传连锁分析表明timpi与更远的鸟氨酸转甲氨基酰基酶（OTC）位点在大约22厘米的距离上相连。这些数据与timp映射到人类X染色体近端短臂和小鼠X染色体中心周围区域的保守共链和连锁组的结论一致，包括synapsin-1、治疗癌基因家族成员OTC和timp的位点。
The gene encoding a tissue inhibitor of metalloproteinases,TIMP, has previously been shown to be X-linked in both the human and mouse genomes. We have used a series of somatic cell hybrids segregating translocation and deletion X chromosomes to map theTIMPgene on the human X chromosome. In combination with previous data, the gene can be assigned to Xp11.23→Xp11.4. Genetic linkage analyses demonstrate thatTIMPis linked to the more distal ornithine transcarbamylase (OTC) locus at a distance of about 22 centimorgans. The data are consistent with the conclusion thatTIMPmaps to a conserved synteny and linkage group on the proximal short arm of the human X chromosome and on the pericentric region of the mouse X chromosome, including loci for synapsin-1, a member of therafoncogene family,OTC, andTIMP.
人β-己糖胺酶α链：编码序列以及与β链的同源性。
DOI：
10.1073/pnas.82.23.7830
发表时间：
1985
影响因子：
11.1
作者：
Myerowitz,R;Piekarz,R;Neufeld,EF;Shows,TB;Suzuki,K
通讯作者：
Suzuki,K