Delayed Contrast Enhanced MRI of Meniscus With Ionic and Non-ionic Agents
Delayed Contrast Enhanced MRI of Meniscus With Ionic and Non-ionic Agents
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DOI：
10.1002/jmri.22477
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发表时间：
2011-03-01
影响因子：
4.4
通讯作者：
Prasad, Pottumarthi V.
中科院分区：
文献类型：
--
作者：
Li, Wei;Edelman, Robert R.;Prasad, Pottumarthi V.
目的：评估骨关节炎患者（OA）和健康受试者（HS）半月板对比后T（1）弛豫时间（T（1Gd））的电位差异，并验证电荷密度是否对半月板T（1Gd）有任何影响。材料和方法：我们对先前获得的用于研究离子和非离子关节软骨的数据进行了关节T（1）弛豫时间的回顾性分析，离子造影剂。在10例OA和8例HS中，在一天给予双倍剂量的离子型Gd-DTPA（2-）和另一天给予非离子型Gd-DTPA-BMA后120 min进行MR成像。结果：与HS相比，OA患者使用离子型Gd-DTPA（2-）（P < 0.01）或非离子型Gd-DTPA-BMA（P < 0.001）造影剂时，半月板的T（1Gd）明显降低。Gd-DTPA（2-）与Gd-DTPA-BMA的T（1）之间存在相关性。半月板T（1）（Gd-DTPA-BMA）显示OA和HS之间的差异较大，重叠较小。无论是前对比T（1）或后对比T（1Gd）之间观察到的内部和外部区域的半月板与任一agent.Conclusion：显着差异，在OA和HS之间的双曲T（1Gd）观察到离子型和非离子型造影剂，这表明电荷密度是不负责所观察到的差异。
Purpose: To evaluate the potential difference in post-contrast T(1) relaxation time of the meniscus (T(1Gd)) between osteoarthritic patients (OA) and healthy subjects (HS), and to verify if charge density has any influence on meniscal T(1Gd).Materials and Methods: We performed a retrospective analysis of meniscal T(1) relaxation time on data previously acquired for studying articular cartilage with both ionic and non-ionic contrast media. MR imaging was performed in 10 OA and 8 HS at 120 min following administration of double-dose ionic Gd-DTPA(2-) on one day and non-ionic Gd-DTPA-BMA on a different day. A three-dimensional Look-Locker sequence with echo time of 2 ms was used for data acquisition to allow T(1) mapping of the meniscus.Results: Compared with HS, significantly lower meniscal T(1Gd) was observed in OA with either ionic Gd-DTPA(2-) (P < 0.01) or non-ionic Gd-DTPA-BMA (P < 0.001) contrast agent. There was a correlation between meniscal T(1)(Gd-DTPA(2-)) versus T(1)(Gd-DTPA-BMA). Meniscal T(1)(Gd-DTPA-BMA) showed a larger difference and smaller overlap between OA and HS. No significant differences in either pre-contrast T(1) or post-contrast T(1Gd) were observed between inner and outer zones of the meniscus with either agent.Conclusion: Significant differences in meniscal T(1Gd) between OA and HS were observed with both ionic and non-ionic contrast agents, suggesting that charge density is not responsible for the observed differences.