Corpus callosum size, reaction time speed and variability in mild cognitive disorders and in a normative sample
Corpus callosum size, reaction time speed and variability in mild cognitive disorders and in a normative sample
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DOI：
10.1016/j.neuropsychologia.2006.11.020
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发表时间：
2007-01-01
期刊：
影响因子：
2.6
通讯作者：
Sachdev, Perminder
中科院分区：
文献类型：
--
作者：
Anstey, Kaarin J.;Mack, Holly A.;Sachdev, Perminder
个体内反应时间的变异性随着年龄和神经系统疾病的增加而增加，但这种变异性增加的神经相关性仍不确定。我们假设更快的平均反应时间（RT）和更少的个体内RT变异性与老年人更大的胼胝体（CC）大小相关，并且这些关联在轻度认知障碍的成年人中更强。比较标准样本（n = 432）和轻度认知障碍样本（n = 57）的CC面积、RT均值和RT变异性（经年龄、性别、教育程度、APOE基因型、吸烟、饮酒、握力、视力、利手性和肺功能调整）。样品在CC面积或颅内体积上没有差异。在规范样本中，简单RT （SRT）和选择RT （CRT）与CC面积呈负相关，但CC面积与个体内部RT变异性之间的相关性很小。在轻度认知障碍样本中，SRT、CRT和SRT任务的个体变异与CC区域相关。在轻度认知障碍的样本中，增加的RT变异性解释了高达12.7%的CC面积方差，但在规范样本中，CC面积方差不到1%。与APOE基因型无相关性。我们得出结论，个体内变异与轻度认知障碍的CC区域有关，但与正常衰老无关。我们认为，在轻度认知障碍中，储备能力的生物学限制必然会导致观察到更强的脑-行为关系。(c) 2006 Elsevier Ltd.版权所有。
Intra-individual variability in reaction time increases with age and with neurological disorders, but the neural correlates of this increased variability remain uncertain. We hypothesized that both faster mean reaction time (RT) and less intra-individual RT variability would be associated with larger corpus callosum (CC) size in older adults, and that these associations would be stronger in adults with mild cognitive disorders. A normative sample (n = 432) and a sample with mild cognitive disorders (it = 57) were compared on CC area, RT mean and RT variability adjusting for age, sex, education, APOE genotype, smoking, alcohol consumption, grip strength, visual acuity, handedness and lung function. Samples did not differ in CC area or intra-cranial volume. In the normative sample, simple RT (SRT) and choice RT (CRT) were negatively associated with CC area but there were minimal associations between CC area and intra-individual RT variability. In the mild cognitive disorders sample, SRT, CRT and intra-individual variability on the SRT task were associated with CC area. Increased RT variability explained up to 12.7 percent of the variance in CC area in the sample with mild cognitive disorders, but less than I percent of the variance in CC area in the normative sample. There were no associations with APOE genotype. We conclude that intra-individual variability is associated with CC area in mild cognitive disorders, but not in normal aging. We propose that biological limits on reserve capacity must occur in mild cognitive disorders that result in stronger brain-behavior relationships being observed. (c) 2006 Elsevier Ltd. All rights reserved.