Serum vascular endothelial growth factor as a surveillance marker for cellular rejection in pediatric cardiac transplantation
Serum vascular endothelial growth factor as a surveillance marker for cellular rejection in pediatric cardiac transplantation
复制标题
DOI：
10.1097/00007890-200201150-00030
复制
发表时间：
2002-01-15
期刊：
影响因子：
6.2
通讯作者：
Crawford, SE
中科院分区：
文献类型：
--
作者：
Abramson, LP;Pahl, E;Crawford, SE
背景。早期发现和治疗心脏移植受者的急性排斥反应可显着提高长期生存率。心内膜心肌活检通常用于诊断同种异体移植排斥反应。然而，对于幼儿来说，这种手术存在一定的风险。我们评估了血清血管内皮生长因子（VEGF）作为急性细胞排斥的潜在监测标志物。方法。对 23 名患者的血液样本 (n=62) 进行了分析，并使用 VEGF ELISA 与对照 (n=18) 进行比较。结果与心内膜心肌活检排斥等级相关。结果。移植群体的平均基线 VEGF 水平始终高于对照组。与非排斥移植组相比，急性细胞排斥期间血清 VEGF 水平显着升高（700.7+/-154 pg/ml vs. 190.5+/-29 pg/ml）。在 11 次排斥反应中有 9 次中，免疫抑制治疗后 VEGF 下降了 2 至 8 倍。结论。这些数据表明 VEGF 可能在急性同种异体移植排斥的发病机制中发挥作用，并且它可以作为可靠的血清学监测标志物。
Background. Early detection and treatment of acute rejection in cardiac transplant recipients significantly improves long-term survival. Endomyocardial biopsy is used routinely for diagnosing allograft rejection; however, in young children, this procedure carries some risk. We evaluated serum vascular endothelial growth factor (VEGF) as a potential surveillance marker of acute cellular rejection.Methods. Blood samples (n=62) were analyzed from 23 patients and compared with controls (n=18) using an ELISA for VEGF. Results were correlated with endomyocardial biopsy rejection grades.Results. Mean baseline VEGF levels of the transplant population were consistently higher than controls. Serum VEGF levels were significantly higher during acute cellular rejection when compared with the non-rejecting transplant group (700.7+/-154 pg/ml vs. 190.5+/-29 pg/ml). VEGF decreased two- to eightfold after immunosuppressive therapy in 9 of 11 rejection episodes.Conclusions. These data suggest that VEGF may play a role in the pathogenesis of acute allograft rejection and it may serve as a reliable serologic surveillance marker.