Expression of tumor necrosis factor alpha and interleukin 1β in jejuna of volunteers after experimental challenge with Cryptosporidium parvum correlates with exposure but not with symptoms
Expression of tumor necrosis factor alpha and interleukin 1β in jejuna of volunteers after experimental challenge with Cryptosporidium parvum correlates with exposure but not with symptoms
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DOI：
10.1128/iai.69.2.1172-1174.2001
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发表时间：
2001-02-01
影响因子：
3.1
通讯作者：
White, AC
中科院分区：
文献类型：
--
作者：
Robinson, P;Okhuysen, PC;White, AC
对用微小隐孢子虫激发的志愿者的空肠活检组织进行肿瘤坏死因子α（TNF-α）和白细胞介素（IL）-1 β mRNA检测，28名志愿者中有15名（54%）的激发后活检组织表达TNF-α; 14%表达IL-1 β。细胞因子表达与肠道症状无关，提示TNF-α和IL-1 β不是人类隐孢子虫病腹泻的关键介质。
Jejunal biopsies from volunteers challenged with Cryptosporidium parvum were examined for tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-1 beta mRNA Postchallenge biopsies from 15 of 28 (54%) volunteers expressed TNF-alpha; 14% expressed IL-1 beta. Cytokine expression did not correlate with enteric symptoms, suggesting that TNF-alpha and IL-1 beta are not key mediators of diarrhea in human cryptosporidiosis.