Betting on dopamine.
Betting on dopamine.
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押注多巴胺。
DOI：
10.1017/s1092852900022574
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发表时间：
2005
期刊：
影响因子：
3.3
通讯作者：
Grant,JonE
中科院分区：
文献类型：
--
作者：
Stein,DanJ;Grant,JonE
案例研究贝蒂是一个59岁的女人谁患有帕金森氏症几年。尝试了各种治疗方法，最终确定了培高利特（一种多巴胺激动剂）和司来吉林（一种单胺氧化酶B型抑制剂）的组合，并获得了合理的结果。没有其他医学或精神病症状的病史，她能够保持良好的生活质量。然而，几个月后，贝蒂报告说，她在刮刮乐卡和老虎机上花了很多时间，并下了价值数百美元的赌注。她早就对这种活动有些兴趣了，不过她手头并不宽裕，之前也只赌了几块钱。她表示，她经常感到紧张，赌博帮助她放松。在检查中，尽管她有一定的言语压力和思想混乱，但她不符合双相II型障碍的诊断标准。她的医生不愿意改变她的帕金森病药物。相反，医生开了低剂量的利培酮（0.5 mg/天，增加到1 mg/天）。她后来报告说对赌博兴趣不大。她的帕金森症状最初恶化，但在辅助低剂量左旋多巴/卡比多巴治疗后有所改善。
CASE STUDY Betty is a 59-year-old woman who has suffered from Parkinson's disease for several years. Various treatments were tried, and a combination of pergolide (a dopamine agonist) and selegeline (a monoamine oxidase type B inhibitor) was eventually settled on with reasonable results. There was no history of other medical or psychiatric symptoms and she was able to maintain a good quality of life. However, after several months, Betty reported that she was spending a good deal of time on scratch lottery cards and slot machines and had placed several hundred dollars worth of bets. She had long had some interest in these kinds of activities, but she was not well-off and had previously limited her betting to only a few dollars. She indicated that she often felt on edge and that betting helped her relax. On examination, although there was some pressure of speech and flight of ideas, she did not meet diagnostic criteria for a bipolar II disorder. Her physician was reluctant to change her Parkinson's disease medications. Instead, the physician prescribed a low dose of risperidone (0.5 mg/day, increasing to 1 mg/day). She subsequently reported less interest in gambling. Her Parkinson's symptoms initially worsened but improved in response to adjuvant low-dose levodopa/carbidopa treatment.