Molecular epidemiology of human enteric caliciviruses in The Netherlands.
Molecular epidemiology of human enteric caliciviruses in The Netherlands.
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荷兰人类肠道杯状病毒的分子流行病学。
DOI：
10.1002/0470846534.ch12
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Y. V. van Duynhoven
中科院分区：
文献类型：
--
作者：
M. Koopmans;J. Vinjé;M. D. de Wit;I. Leenen;W. V. D. van der Poel;Y. V. van Duynhoven
在荷兰，由杯状病毒科的诺瓦克样病毒（NLV）引起的疾病相当常见。在向市公共卫生中心报告的胃肠炎暴发中，NLV引起的占80%以上，在向全科医生咨询的胃肠炎病例中，至少有5%是由NLV引起的。此外，在1998/1999年冬季，高达18%的社区胃肠炎病例归因于非线性车辆。疾病活动的模式明显不同，“正常年份，当爆发是由不同类型的NLV引起的，“流行年份，当爆发似乎是由单一菌株引起的。这一观察结果表明选择具有增加的毒力或改变的传播模式的抗原变体。此外，由于在荷兰45%的奶牛场的小牛粪便标本中检测到了与人类NLV相关的杯状病毒，因此应考虑动物宿主向人类传播流行毒株的可能性。
In The Netherlands, illness due to Norwalk-like viruses (NLVs) of the family Caliciviridae is quite common. NLVs cause >80% of the outbreaks of gastroenteritis reported to municipal public health centers and at least 5% of the cases of gastroenteritis for which a general practitioner is consulted. In addition, up to 18% of community cases of gastroenteritis in the 1998/1999 winter season have been attributed to NLVs. Patterns of disease activity differ remarkably, with "normal years, when outbreaks occur that are caused by different types of NLV, and "epidemic years, when outbreaks appear to be caused by a single strain. This observation suggests selection of antigenic variants with increased virulence or altered modes of transmission. In addition, since caliciviruses related to the NLVs from humans have been detected in stool specimens from calves at 45% of the dairy farms in The Netherlands, the possibility of spillover of epidemic strains from an animal reservoir to humans should be considered.