Engineering nature for gaseous hydrocarbon production.
Engineering nature for gaseous hydrocarbon production.
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DOI：
10.1186/s12934-020-01470-6
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发表时间：
2020-11-13
影响因子：
6.4
通讯作者：
Scrutton NS
中科院分区：
文献类型：
--
作者：
Amer M;Toogood H;Scrutton NS
开发生物制造气态碳氢化合物的可持续途径将广泛有助于满足未来的能源需求。这些目标的实现将有助于减少对化石燃料的过度依赖，改善空气质量，减少碳足迹并提高整体能源安全。烷烃气体（丙烷、丁烷和异丁烷）是高效和清洁燃烧的燃料。它们在全球交通运输行业中建立，用于家庭供暖和烹饪，非温室气体制冷剂和气溶胶推进剂。由于没有发现短链烷烃的天然生物合成途径，因此已经设计了从头途径。这些途径结合了两种酶之一，醛脱甲酰加氧酶或脂肪酸光脱羧酶，以催化导致气体形成的最后一步。这些新途径源自脂肪酸生物合成、丁醇生产的反向β-氧化、缬氨酸生物合成和氨基酸降解的既定途径。在体内单步生产烷烃气体也是可能的，其中一种重组生物催化剂可以催化从外源供应的短链脂肪酸前体形成气体。本综述探讨了生物烷烃气体生产的当前进展，并强调了实施可扩展和可持续商业生物生产中心的潜力。
The development of sustainable routes to the bio-manufacture of gaseous hydrocarbons will contribute widely to future energy needs. Their realisation would contribute towards minimising over-reliance on fossil fuels, improving air quality, reducing carbon footprints and enhancing overall energy security. Alkane gases (propane, butane and isobutane) are efficient and clean-burning fuels. They are established globally within the transportation industry and are used for domestic heating and cooking, non-greenhouse gas refrigerants and as aerosol propellants. As no natural biosynthetic routes to short chain alkanes have been discovered, de novo pathways have been engineered. These pathways incorporate one of two enzymes, either aldehyde deformylating oxygenase or fatty acid photodecarboxylase, to catalyse the final step that leads to gas formation. These new pathways are derived from established routes of fatty acid biosynthesis, reverse β-oxidation for butanol production, valine biosynthesis and amino acid degradation. Single-step production of alkane gases in vivo is also possible, where one recombinant biocatalyst can catalyse gas formation from exogenously supplied short-chain fatty acid precursors. This review explores current progress in bio-alkane gas production, and highlights the potential for implementation of scalable and sustainable commercial bioproduction hubs.
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影响因子：
3
作者：
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影响因子：
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作者：
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DOI：
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影响因子：
3.1
作者：
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影响因子：
6.3
作者：
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DOI：
10.1002/anie.201807119
发表时间：
2018-10-08
期刊：
Angewandte Chemie (International ed. in English)
影响因子：
--
作者：
Huijbers MME;Zhang W;Tonin F;Hollmann F
通讯作者：
Hollmann F