The emerging role of outdoor and indoor air pollution in cardiovascular disease.
The emerging role of outdoor and indoor air pollution in cardiovascular disease.
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DOI：
10.4103/1947-2714.117290
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发表时间：
2013-08
期刊：
影响因子：
--
通讯作者：
Garelnabi M
中科院分区：
文献类型：
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作者：
Uzoigwe JC;Prum T;Bresnahan E;Garelnabi M
室外和室内空气污染具有显著的心血管风险，并与动脉粥样硬化有关，动脉粥样硬化是许多心血管疾病的主要潜在病理。虽然众所周知，接触空气污染会导致肺部疾病，但最近的研究表明，空气污染对心血管健康造成的后果通常等于或超过肺部疾病造成的后果。本文的目的是评估环境空气污染在心血管疾病中新出现的作用的现有证据，特别关注空气污染物的类型和空气污染诱导心脏毒性的机制。本文系统地回顾和引用了已发表的有关污染的文献。希望这一综述将有助于更好地了解空气污染暴露对心血管的有害影响。这将有助于更好地了解可能的预防保健措施，也将为监管机构和研究人员服务。此外，阐明空气污染与心血管疾病之间联系的生物学机制是开发旨在减少空气污染对心血管系统不利影响的新药理学策略的重要目标。
Outdoor and indoor air pollution poses a significant cardiovascular risk, and has been associated with atherosclerosis, the main underlying pathology in many cardiovascular diseases. Although, it is well known that exposure to air pollution causes pulmonary disease, recent studies have shown that cardiovascular health consequences of air pollution generally equal or exceed those due to pulmonary diseases. The objective of this article is to evaluate the current evidence on the emerging role of environmental air pollutions in cardiovascular disease, with specific focus on the types of air pollutants and mechanisms of air pollution-induced cardiotoxicity. Published literature on pollution was systematically reviewed and cited in this article. It is hoped that this review will provide a better understanding of the harmful cardiovascular effects induced by air pollution exposure. This will help to bring a better understanding on the possible preventive health measures and will also serve regulatory agencies and researchers. In addition, elucidating the biological mechanisms underlying the link between air pollution and cardiovascular disease is an essential target in developing novel pharmacological strategies aimed at decreasing adverse effects of air pollution on cardiovascular system.