Biliary cholesterol secretion: More than a simple ABC
Biliary cholesterol secretion: More than a simple ABC
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DOI：
10.3748/wjg.v16.i47.5936
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发表时间：
2010-12-21
影响因子：
4.3
通讯作者：
Tietge, Uwe J. F.
中科院分区：
文献类型：
--
作者：
Dikkers, Arne;Tietge, Uwe J. F.
胆汁胆固醇分泌是两大疾病复合体、动脉粥样硬化性心血管疾病和胆固醇结石疾病的重要过程。胆汁胆固醇分泌被认为是通过胆固醇反向转运途径清除胆固醇起源于血管壁巨噬细胞泡沫细胞的胆固醇的最后一步。另一方面，胆汁中胆固醇的高分泌被认为是胆固醇结石形成的主要病理生理决定因素。本文综述了胆固醇分泌到胆汁的起源以及与已建立的介导胆汁酸分泌的三磷酸腺苷结合盒(ABC)转运体(AB11)有关的相关过程和转运体的现有知识。磷脂(ABCB4)和胆固醇(ABCG5/G8)，特别关注调节或介导胆汁胆固醇分泌的新出现的蛋白质。在这方面，讨论了磷脂酰丝氨酸反转酶I型8B成员1、介导胆固醇吸收的尼曼Pick类蛋白1和高密度脂蛋白胆固醇摄取受体B型清道夫受体的潜在影响。(C)2010白石登版权所有
Biliary cholesterol secretion is a process important for 2 major disease complexes, atherosclerotic cardiovascular disease and cholesterol gallstone disease With respect to cardiovascular disease, biliary cholesterol secretion is regarded as the final step for the elimination of cholesterol originating from cholesterol laden macrophage foam cells in the vessel wall in a pathway named re verse cholesterol transport On the other hand, cholesterol hypersecretion into the bile is considered the main pathophysiological determinant of cholesterol gallstone formation This review summarizes current knowledge on the origins of cholesterol secreted into the bile as well as the relevant processes and transporters involved Next to the established ATP binding cassette (ABC) transporters mediating the biliary secretion of bile acids (ABCB11), phospholipids (ABCB4) and cholesterol (ABCG5/G8), special attention is given to emerging proteins that modulate or mediate biliary cholesterol secretion In this regard, the potential impact of the phosphatidylserine flippase ATPase class I type 8B member 1, the Niemann Pick C1 like protein 1 that mediates cholesterol absorption and the high density lipoprotein cholesterol uptake receptor, scavenger receptor class B type I, is discussed (C) 2010 Baishideng All rights reserved