Genetic control of meristem arrest and life span in Arabidopsis by a FRUITFULL-APETALA2 pathway.

Genetic control of meristem arrest and life span in Arabidopsis by a FRUITFULL-APETALA2 pathway.
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DOI:
10.1038/s41467-018-03067-5
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发表时间:
2018-02-08
影响因子:
16.6
通讯作者:
Ferrándiz C
Ferrándiz C
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Balanzà V;Martínez-Fernández I;Sato S;Yanofsky MF;Kaufmann K;Angenent GC;Bemer M;Ferrándiz C

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单果植物在其生命中具有单一的繁殖周期,其寿命由所有分生组织的协调停滞或全局增殖停滞(GPA)决定。除了未知性质的种子发育产生的系统线索外,GPA 的分子基础和所涉及的信号传导机制尚不清楚。在这里,我们发现了拟南芥中调节 GPA 的遗传途径,该途径对年龄依赖性因素做出反应,并与种子来源的信号平行发挥作用。我们发现 FRUITFULL (FUL) 是一种参与开花和果实发育的 MADS-box 基因,在促进分生组织停滞中具有关键作用,因为在 ful 突变体中 GPA 被延迟并且果实产量增加。 FUL 直接负向调节茎尖分生组织中 APETALA2 的表达,并维持 WUSCHEL 的时间表达,而 WUSCHEL 是分生组织维持的重要因素。单果植物的寿命是由芽分生组织的协调停滞决定的。作者在此表明,这一过程是由 FRUITFULL 转录因子促进的,该转录因子以 AP2 依赖性方式负向调节分生组织维持因子 WUSCHEL 的表达。
Monocarpic plants have a single reproductive cycle in their lives, where life span is determined by the coordinated arrest of all meristems, or global proliferative arrest (GPA). The molecular bases for GPA and the signaling mechanisms involved are poorly understood, other than systemic cues from developing seeds of unknown nature. Here we uncover a genetic pathway regulating GPA in Arabidopsis that responds to age-dependent factors and acts in parallel to seed-derived signals. We show that FRUITFULL (FUL), a MADS-box gene involved in flowering and fruit development, has a key role in promoting meristem arrest, as GPA is delayed and fruit production is increased in ful mutants. FUL directly and negatively regulates APETALA2 expression in the shoot apical meristem and maintains the temporal expression of WUSCHEL which is an essential factor for meristem maintenance. The lifespan of monocarpic plants is determined by coordinated arrest of shoot meristems. Here the authors show that this process is promoted by the FRUITFULL transcription factor which negatively regulates expression of the meristem maintenance factor WUSCHEL in an AP2-dependent manner.
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