Neurogenic tumors in coho salmon (Oncorhynchus kisutch) reared in well water in Japan.
Neurogenic tumors in coho salmon (Oncorhynchus kisutch) reared in well water in Japan.
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日本井水中饲养的银大麻哈鱼（Oncorhynchus kisutch）的神经源性肿瘤。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
K. Ikeda
中科院分区：
文献类型：
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作者：
P. Masahito;T. Ishikawa;A. Yanagisawa;H. Sugano;K. Ikeda
神经源性肿瘤被发现从23个银鲑身体的各个部位突出。携带肿瘤的鱼是从美国进口到日本的第一代或第二代鱼，这些鱼的卵在眼睛阶段。22例肿瘤发生在年轻人中，最大直径为14至80 mm。组织学上，肿瘤由梭形细胞和丰富的纤维间质组成。1例肿瘤呈典型的栅栏状核。所有年轻成人肿瘤均侵犯局部肌肉和脂肪组织。这些肿瘤的组织学表现与人类恶性神经鞘瘤相似。在银鲑鱼种中发现的一个肿瘤被鉴定为室管膜母细胞瘤。Vectstain抗生物素蛋白-生物素-过氧化物酶复合物免疫过氧化物酶染色的S-100蛋白的程序显示，S-100蛋白存在于室管膜母细胞瘤和典型的核栅栏的恶性神经鞘瘤在银鲑鱼的领域。银鲑软组织肿瘤的发生在日本首次记录。本病例的形态学和病因学与美国报道的鲑鱼肿瘤进行了比较。从鱼的饲养条件来看，这些肿瘤的发展与水氯化过程中形成的卤代化合物无关，如前所述。导致其发展的环境因素尚未确定，遗传影响可能是一个促成因素。
Neurogenic tumors were found protruding from various parts of the body of 23 coho salmon. The tumor-bearing fish were first- or second-generation fish derived from eggs imported at the eyed stage to Japan from the United States. Twenty-two of the tumors were in young adults and varied from 14 to 80 mm in maximum diameter. Histologically, the tumors were composed of spindle-shaped cells with abundant fibrous stroma. One tumor showed typical nuclear palisading. All tumors in young adults invaded locally muscle and adipose tissues. These tumors were similar in histologic appearance to malignant schwannomas in humans. One tumor found in a fingerling coho salmon was identified as an ependymoblastoma. The Vectstain avidin-biotin-peroxidase complex immunoperoxidase staining procedure for S-100 protein revealed that the S-100 protein existed in an ependymoblastoma and in areas of typical nuclear palisading in a malignant schwannoma in coho salmon. The occurrence of soft tissue tumors in coho salmon was first recorded in Japan. The morphology and etiology of the present cases were compared with those of the tumors in salmon reported from the United States. Judging from the conditions in which the fish were reared, the development of these tumors was not related to halogenated compounds formed during water chlorination, as suggested previously. The environmental factor(s) responsible for their development has not yet been identified, and genetic influences may have been a contributory factor.