PHENCYCLIDINE BINDING-SITES IN THE NUCLEUS ACCUMBENS AND PHENCYCLIDINE-INDUCED HYPERACTIVITY ARE DECREASED FOLLOWING LESIONS OF THE MESOLIMBIC DOPAMINE SYSTEM
PHENCYCLIDINE BINDING-SITES IN THE NUCLEUS ACCUMBENS AND PHENCYCLIDINE-INDUCED HYPERACTIVITY ARE DECREASED FOLLOWING LESIONS OF THE MESOLIMBIC DOPAMINE SYSTEM
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DOI：
10.1016/0014-2999(85)90178-5
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发表时间：
1985-01-01
影响因子：
5
通讯作者：
QUIRION, R
中科院分区：
文献类型：
--
作者：
FRENCH, ED;PILAPIL, C;QUIRION, R
选择性损毁大鼠中脑边缘多巴胺能系统，观察苯环利定([~3H]PCP)与大鼠伏隔核、海马膜和纹状体膜的结合，以及PCP引起的运动亢进。将6-羟基多巴胺(6-OHDA)注入伏隔腹侧被盖区A10区或伏核本身，可阻断PCP的兴奋作用，使伏核[~3H]PCP结合部位数和多巴胺含量显著减少。然而，破坏多巴胺能中脑边缘纤维并没有显著改变海马区或纹状体的[~3H]PCP结合。这些数据表明，PCP通过与主要位于伏核内的中脑边缘多巴胺能终末的PCP结合部位的相互作用而产生其运动刺激效应。
[3H]Phencyclidine ([3H]PCP) binding to rat nucleus accumbens, hippocampal and striatal membranes, and PCP-induced locomotor hyperactivity were assessed following selective lesions of the mesolimbic dopaminergic system. 6-Hydroxydopamine (6-OHDA) injections into the A10 region of the ventral tegmental area or into the accumbens itself resulted in a blockade of PCP stimulatory effects and a highly significant reduction in the number of [3H]PCP binding sites and dopamine content of the nucleus accumbens. However, destruction of the dopaminergic mesolimbic fibers did not significantly alter hippocampal or striatal [3H]PCP binding. The data suggest that PCP elicits its locomotor stimulating effects via an interaction with PCP binding sites located mostly on mesolimbic dopaminergic terminals within the nucleus accumbens.