Role of TLR2-dependent inflammation in metastatic progression.

Role of TLR2-dependent inflammation in metastatic progression.
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DOI:
10.1111/j.1749-6632.2010.05882.x
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发表时间:
2011-01
影响因子:
5.2
通讯作者:
Karin M
Karin M
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Kim S;Karin M

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炎症是宿主防御系统的一部分,它提供对入侵病原体的保护。然而,越来越清楚的是,内源性介质可以通过Toll样受体(TLR)诱发炎症,从而促进肿瘤的进展和转移。在这里,我们讨论了TLR介导的炎症在肿瘤进展中的作用,以及它实现这种致病功能的机制。
Inflammation is a part of the host defense system, which provides protection against invading pathogens. However, it has become increasingly clear that inflammation can be evoked by endogenous mediators through Toll-like receptors (TLRs) to enhance tumor progression and metastasis. Here, we discuss the roles of TLR-mediated inflammation in tumor progression and the mechanisms through which it accomplishes this pathogenic function.
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