Mapping cortical gray matter in the young adult brain: Effects of gender
Mapping cortical gray matter in the young adult brain: Effects of gender
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DOI：
10.1016/j.neuroimage.2005.02.010
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发表时间：
2005-06-01
期刊：
影响因子：
5.7
通讯作者：
Toga, AW
中科院分区：
文献类型：
--
作者：
Luders, E;Narr, KL;Toga, AW
使用磁共振成像和经过验证的计算皮层模式匹配方法，在一个大的和匹配良好的健康受试者的样本，我们分析了性别对区域灰质（GM）浓度的影响在整个皮层。为了澄清以前报告中的差异，我们还研究了全脑组织体积的性别二态性，并没有控制脑大小的差异。此外，我们生成了空间上详细的地图，平均GM分布和变异性在整个皮层，这些描述符没有得到很好的表征，在规范性文献。大脑大小校正后，我们检测到许多皮质区域显示显着增加GM浓度的女性相比，男性，但没有区域增加GM浓度的男性。排列测试证实了这些发现的统计学意义。女性皮质GM浓度的局部增加证实了女性在校正个体大脑大小后的更大的全球GM体积的发现。然而，当不考虑个体脑体积时，在雄性动物中观察到GM、白色物质和CSF的整体体积较大。我们的研究结果表明，性别是个体之间区域和全球GM差异的主要贡献者，尽管这些影响的性质取决于是否考虑到大脑大小。(c)2005年爱思唯尔公司All rights reserved.
Using magnetic resonance imaging and well-validated computational cortical pattern matching methods in a large and well-matched sample of healthy subjects, we analyzed the effects of gender on regional gray matter (GM) concentration across the cortex. To clarify discrepancies in previous reports, we also examined sexual dimorphisms for whole-brain tissue volumes with and without controlling for brain size differences. In addition, we generated spatially detailed maps of average GM distributions and variability across the entire cortex given that these descriptors are not well characterized in the normative literature. After brain size correction, we detected numerous cortical regions showing significantly increased GM concentration in females compared to males, but no regionally increased GM concentration in males. Permutation testing confirmed the statistical significance of these findings. Locally increased concentration of cortical GM in females corroborates findings of larger global GM volumes in females after correcting for individual brain sizes. Larger global volumes of GM, white matter and CSF, however, are observed in males when individual brain volumes are not taken into account. Our results show that gender is a major contributor to regional and global GM differences between individuals, although the nature of these effects depend on whether brain size is taken into account. (c) 2005 Elsevier Inc. All rights reserved.