PSYCHIATRIC HISTORY AND RELATED EXPOSURES AS RISK-FACTORS FOR ALZHEIMERS-DISEASE - A COLLABORATIVE REANALYSIS OF CASE-CONTROL STUDIES
PSYCHIATRIC HISTORY AND RELATED EXPOSURES AS RISK-FACTORS FOR ALZHEIMERS-DISEASE - A COLLABORATIVE REANALYSIS OF CASE-CONTROL STUDIES
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DOI：
10.1093/ije/20.supplement_2.s43
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发表时间：
1991-01-01
影响因子：
7.7
通讯作者：
HOFMAN, A
中科院分区：
文献类型：
--
作者：
JORM, AF;VANDUIJN, CM;HOFMAN, A
本文收集了阿尔茨海默病（AD）病例对照研究的资料，以探讨抑郁症史、抗抑郁治疗和不良生活事件作为危险因素的可能作用。 抑郁症的历史被发现与AD，虽然效果仅限于晚发病例。 这种关联适用于AD发病前10年以上的抑郁发作，以及发病后10年内发生的抑郁发作。 未发现与抗癫痫治疗相关。 然而，只有两项研究的数据，限制了分析的能力。 此外，在汇总分析中没有发现与三个主要生活事件的关联：配偶死亡，子女死亡和离婚。
Data from case-control studies of Alzheimer's disease (AD) were pooled to examine the possible roles of history of depression, anti-depressant treatment and adverse life events as risk factors. History of depression was found to be associated with AD, although the effect was confined to late onset cases. The association held for episodes of depression more than 10 years before AD onset, as well as for episodes occurring within a decade of onset. No association was found with anti-depressant treatment. However, data were only available from two studies, limiting the power of the analysis. Also, no association was found with the three major life events considered in the pooled analysis: death of spouse, death of a child and divorce.